[{"idx":105366,"drug_code":"2020041700010","drug_name":"\uB51C\uB77C\uD2B8\uB80C\uC5D0\uC2A4\uC54C\uC8158mg","drug_enm":"Dilatren SR Tab. 8mg","noins":null,"narcotic_kind_code":" ","list_sunb_name":"Carvedilol Granule 43.9mg","cls_code_num":"214","sunb":"<a href=\"\/searchIngredient\/detail.asp?ingd_code=I000367\">Carvedilol Granule\u3000\uCE74\uB974\uBCA0\uB51C\uB864\uACFC\uB9BD\u300043.9mg (\uCE74\uB974\uBCA0\uB51C\uB864(\uC73C)\uB85C\uC11C 8mg)<\/a>@","drug_cls":"1","sunb_count":1,"upso_name":"\uC885\uADFC\uB2F9|Chong Kun Dang Pharmaceutical Corp.|(120-756) \uC11C\uC6B8 \uC11C\uB300\uBB38\uAD6C \uCDA9\uC815\uB85C 3\uAC00 368|02) 2194-0300, 3149-7800|02) 2194-0369|http:\/\/www.ckdpharm.com","upso1":"","drug_form":"\uC11C\uBC29\uC815","dosage_route":"\uACBD\uAD6C(\uB0B4\uC6A9\uACE0\uD615)","charact":"\uBD84\uD64D\uC0C9\uC758 \uC7A5\uBC29\uD615 \uC11C\uBC29\uC815","charact_new":"\uBD84\uD64D\uC0C9\uC758 \uC7A5\uBC29\uD615 \uC11C\uBC29\uC815","cls_code":"\uD608\uC555\uAC15\uD558\uC81C","atc_cd":"C07AG02|CARVEDILOL|\uCE74\uB974\uBCA0\uB51C\uB864","boh_history":null,"boh_hiracode":null,"item_permit_date":"20200416","cancel_date":"0","newdrug_class_code":"N","bioeq_prodt_yn":"N","comp_drug_yn_biology":"N","comp_drug_yn_effect":"N","comp_drug_yn":"N","comp_drug_yn_physicochemical":"N","kpic_atc":"Carvedilol Granule : <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C\">\uC21C\uD658\uAE30\uACC4\uC9C8\uD658<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C01\">\uACE0\uD608\uC555 \uCE58\uB8CC\uC81C<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C01A\">\uBCA0\uD0C0-\uCC28\uB2E8\uC81C<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C01AC\">\u03B1,\u03B2-\uCC28\uB2E8<\/a>|Carvedilol Granule : <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C\">\uC21C\uD658\uAE30\uACC4\uC9C8\uD658<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C02\">\uD611\uC2EC\uC99D \uCE58\uB8CC\uC81C<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C02C\">\uBCA0\uD0C0-\uCC28\uB2E8\uC81C<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C02CC\">\u03B1,\u03B2-\uCC28\uB2E8<\/a>|Carvedilol Granule : <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C\">\uC21C\uD658\uAE30\uACC4\uC9C8\uD658<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C03\">\uC2EC\uBD80\uC804 \uCE58\uB8CC\uC81C<\/a> >  <a href=\"\/renewal\/searchIngredient\/KPICeffect.asp?kpic_atc_cd=C03D\">\uBCA0\uD0C0-\uCC28\uB2E8\uC81C<\/a>","kpic_atc_cd":"C01AC02|C02CC02|C03DA02","insertpaper":"","paper_dt":"","dur_age":"","dur_contra":"","dur_preg":"Carvedilol : 2\uB4F1\uAE09 , \uBA85\uD655\uD55C \uC784\uC0C1\uC801 \uADFC\uAC70 \uB610\uB294 \uC0AC\uC720\uAC00 \uC788\uB294 \uACBD\uC6B0 \uBD80\uB4DD\uC774\uD558\uAC8C \uC0AC\uC6A9","dur_senior":"","dur_dose":"Carvedilol  : 1\uC77C \uCD5C\uB300 \uD22C\uC5EC\uB7C9 - \uCE74\uB974\uBCA0\uB51C\uB864 128mg","dur_period":"","dur_donate":"","dur_form":"\uBD84\uD560 \uD22C\uC5EC \uC2DC \uC6D0\uD558\uB294 \uC57D\uD6A8\uB97C \uC5BB\uC744 \uC218 \uC5C6\uAC70\uB098 \uBD80\uC791\uC6A9\uC774 \uBC1C\uC0DD\uD560 \uC218 \uC788\uC73C\uBBC0\uB85C \uC8FC\uC758 \uD544\uC694","fdacode":"C\/\uC784\uC2E0 2\uAE30, 3\uAE30\uC5D0 \uC0AC\uC6A9\uC2DC D","fdacontent":"\uC784\uC2E0 2\uAE30, 3\uAE30\uC5D0 \uC0AC\uC6A9\uC2DC DC \uB4F1\uAE09 : \uD0DC\uC544\uC5D0 \uB300\uD55C \uC704\uD5D8\uC131\uC744 \uC644\uC804\uD788 \uBC30\uC81C\uD560 \uC218 \uC5C6\uC74C. 1) \uC0AC\uB78C\uACFC \uB3D9\uBB3C \uBAA8\uB450\uC5D0\uC11C \uC801\uC808\uD558\uACE0 \uC798 \uD1B5\uC81C\uB41C \uC5F0\uAD6C \uC790\uB8CC\uAC00 \uC5C6\uB294 \uACBD\uC6B0. \uB610\uB294, 2) \uC0AC\uB78C\uC5D0 \uB300\uD574 \uC801\uC808\uD558\uACE0 \uC798 \uD1B5\uC81C\uB41C \uC5F0\uAD6C \uC790\uB8CC\uB294 \uC5C6\uC73C\uB098, \uB3D9\uBB3C\uC5D0 \uB300\uD55C \uC5F0\uAD6C \uACB0\uACFC \uD0DC\uC790\uC5D0 \uB300\uD55C \uC704\uD5D8\uC131\uC774 \uB098\uD0C0\uB09C \uACBD\uC6B0. \uD574\uB2F9 \uC57D\uBB3C\uC774 \uC784\uBD80\uC5D0\uAC8C \uD22C\uC5EC\uB420 \uACBD\uC6B0 \uD0DC\uC544\uC5D0\uAC8C \uC704\uD5D8\uD560 \uAC00\uB2A5\uC131\uB3C4 \uC788\uC73C\uB098, \uC57D\uBB3C\uD22C\uC5EC\uB85C \uC778\uD55C \uCE58\uB8CC\uC801 \uC774\uB4DD\uC774 \uC704\uD5D8\uC744 \uC0C1\uD68C\uD560 \uAC00\uB2A5\uC131\uC774 \uC788\uB2E4.","sunbcontent":"Carvedilol Granule|C|\uACBD\uAD6C\uC81C|\uC784\uC2E0 2\uAE30, 3\uAE30\uC5D0 \uC0AC\uC6A9\uC2DC D#","drug_box":"30\uC815\/\uBCD1,100\uC815\/\uBCD1","stmt":"\uC2E4\uC628\uBCF4\uAD00(1~30\u2103), \uAE30\uBC00\uC6A9\uAE30","drug_pic":"|https:\/\/common.health.kr\/shared\/images\/sb_photo\/big3\/202004170001002.jpg","pack_img":"","picto_img":"https:\/\/common.health.kr\/shared\/images\/pictogram\/black\/kor\/P01.jpg|https:\/\/common.health.kr\/shared\/images\/pictogram\/black\/kor\/C05.jpg|https:\/\/common.health.kr\/shared\/images\/pictogram\/black\/kor\/C21.jpg|https:\/\/common.health.kr\/shared\/images\/pictogram\/black\/kor\/C25.jpg","medititle":"\uC2EC\uBC15\uB3D9\uC218\uB97C \uAC10\uC18C\uC2DC\uD0A4\uACE0 \uD608\uAD00\uD655\uC7A5\uD6A8\uACFC\uAC00 \uC788\uC5B4 \uD608\uC555\uC744 \uB0AE\uCD94\uACE0 \uC2EC\uC7A5\uBD80\uB2F4\uC744 \uAC10\uC18C\uC2DC\uD0A4\uB294 \uC57D\uC785\uB2C8\uB2E4.","mediguide":"- \uC99D\uC0C1\uC774 \uAC1C\uC120\uB418\uB354\uB77C\uB3C4 \uC804\uBB38\uAC00\uC640 \uC0C1\uC758\uC5C6\uC774 \uD22C\uC57D\uC744 \uC911\uB2E8\uD558\uC9C0 \uB9C8\uC138\uC694.brbr- \uC5B4\uC9C0\uB7FD\uAC70\uB098 \uC878\uC74C\uC774 \uC62C \uC218 \uC788\uC73C\uBBC0\uB85C \uC6B4\uC804, \uC704\uD5D8\uD55C \uAE30\uACC4\uC870\uC791\uC2DC \uC8FC\uC758\uD558\uC138\uC694.brbr- \uB9E5\uBC15 \uC18D\uB3C4\uAC00 \uD604\uC800\uD788 \uB2EC\uB77C\uC9C0\uAC70\uB098 \uBD88\uADDC\uCE59\uD574\uC9C0\uBA74 \uC804\uBB38\uAC00\uC640 \uC0C1\uC758\uD558\uC138\uC694.brbr- \uCC9C\uC2DD \uD658\uC790\uB098 \uADF8 \uBCD1\uB825\uC774 \uC788\uB294 \uACBD\uC6B0 \uC804\uBB38\uAC00\uC5D0\uAC8C \uBBF8\uB9AC \uC54C\uB9AC\uC138\uC694.","effect":"1. \uBCF8\uD0DC\uACE0\uD608\uC555brbr<P><\/P>2. \uB9CC\uC131 \uC548\uC815\uD611\uC2EC\uC99Dbrbr<P><\/P>3. \uC6B8\uD608\uC2EC\uBD80\uC804brbr<P><\/P>\uC774\uB1E8\uC81C, \uB514\uAE30\uD0C8\uB9AC\uC2A4 \uC81C\uC81C, ACE \uC5B5\uC81C\uC81C, \uAE30\uD0C0 \uD608\uAD00\uD655\uC7A5\uC81C \uD22C\uC5EC \uC2DC \uBCF4\uC870\uCE58\uB8CCbrbr<P><\/P>4. \uC2EC\uBC29\uC138\uB3D9 \uD658\uC790\uC5D0\uC11C\uC758 \uC2EC\uBC15\uC218 \uC870\uC808brbr<P><\/P>","dosage":"\uC774 \uC57D\uC740 \uC2DD\uC0AC\uC640 \uD568\uAED8 \uACBD\uAD6C\uD22C\uC5EC\uD558\uBA70, \uC758\uC0AC\uC758 \uC9C0\uC2DC \uC5C6\uC774 \uC6A9\uB7C9\uC744 \uC99D\uAC00\uC2DC\uD0A4\uAC70\uB098 \uD22C\uC5EC\uB97C \uC911\uB2E8\uD558\uC5EC\uC11C\uB294 \uC548 \uB41C\uB2E4.brbr<P><\/P>\uC774 \uC57D\uC740 \uC11C\uBC29\uC131 \uC81C\uC81C\uC774\uBBC0\uB85C \uBD80\uC218\uAC70\uB098, \uBD84\uC1C4\uD558\uAC70\uB098 \uB610\uB294 \uC539\uC5B4\uC11C \uBCF5\uC6A9\uD574\uC11C\uB294 \uC548\uB418\uBA70, \uC815\uC81C \uC804\uCCB4\uB97C \uC0BC\uCF1C\uC11C \uBCF5\uC6A9\uD55C\uB2E4.brbr<P><\/P>\uCC38\uACE0\uB85C \uCE74\uB974\uBCA0\uB51C\uB864 \uC77C\uBC18\uC81C\uC81C\uC5D0 \uC0C1\uC751\uD558\uB294 \uC774 \uC57D(\uC11C\uBC29\uC131 \uC81C\uC81C)\uC758 1\uC77C \uC6A9\uB7C9\uC740 \uB2E4\uC74C\uACFC \uAC19\uB2E4.brbr<P><\/P>brbr<TABLE style=\"TEXT-INDENT: 0px\" cellSpacing=0 borderColorDark=white borderColorLight=black border=1>brbr<TBODY>brbr<TR>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">\uC77C\uBC18 \uC81C\uC81C\uC758 1\uC77C \uC6A9\uB7C9<\/P><\/TD>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">\uC11C\uBC29\uC131 \uC81C\uC81C\uC758 1\uC77C \uC6A9\uB7C9<\/P><\/TD><\/TR>brbr<TR>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 2\uD68C, 1\uD68C 3.125mg<\/P><\/TD>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 1\uD68C, 1\uD68C 8mg<\/P><\/TD><\/TR>brbr<TR>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 2\uD68C, 1\uD68C 6.25mg<\/P><\/TD>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 1\uD68C, 1\uD68C 16mg<\/P><\/TD><\/TR>brbr<TR>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 2\uD68C, 1\uD68C 12.5mg<\/P><\/TD>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 1\uD68C, 1\uD68C 32mg<\/P><\/TD><\/TR>brbr<TR>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 2\uD68C, 1\uD68C 25mg<\/P><\/TD>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 1\uD68C, 1\uD68C 64mg<\/P><\/TD><\/TR>brbr<TR>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 2\uD68C, 1\uD68C 50mg<\/P><\/TD>brbr<TD style=\"WIDTH: 225.4pt; VERTICAL-ALIGN: top\">brbr<P style=\"TEXT-ALIGN: center; MARGIN-LEFT: 0cm; MARGIN-RIGHT: 0cm\">1\uC77C 1\uD68C, 1\uD68C 128mg<\/P><\/TD><\/TR><\/TBODY><\/TABLE>1. \uBCF8\uD0DC\uACE0\uD608\uC555brbr<P><\/P>1) \uC131\uC778: \uC774 \uC57D\uC73C\uB85C\uC11C 1\uC77C 1\uD68C 16mg\uC744 2\uC77C\uAC04 \uD22C\uC5EC\uD55C \uD6C4 1\uC77C 1\uD68C 32mg\uC73C\uB85C \uC99D\uB7C9\uD55C\uB2E4. \uD1B5\uC0C1 1\uC77C 1\uD68C 32mg\uC744 2\uC8FC\uAC04 \uD22C\uC5EC\uD55C \uD6C4 \uD6A8\uACFC\uAC00 \uCDA9\uBD84\uD558\uC9C0 \uC54A\uC744 \uACBD\uC6B0 \uD22C\uC5EC\uB7C9\uC744 1\uC77C 1\uD68C 64mg\uC73C\uB85C \uC99D\uB7C9\uD560 \uC218 \uC788\uB2E4.brbr<P><\/P>\uC774 \uC57D\uC758 1\uC77C \uCD5C\uB300 \uBCF5\uC6A9\uB7C9\uC740 64mg\uC774\uB2E4.brbr<P><\/P>2) \uACE0\uB839\uC790: \uC774 \uC57D 1\uC77C 1\uD68C 16mg \uD22C\uC5EC\uB85C \uCDA9\uBD84\uD55C \uCE58\uB8CC\uD6A8\uACFC\uB97C \uB098\uD0C0\uB0BC \uC218 \uC788\uB2E4. 2\uC8FC \uD22C\uC5EC \uD6C4 \uD6A8\uACFC\uAC00 \uCDA9\uBD84\uD558\uC9C0 \uC54A\uC744 \uACBD\uC6B0 \uC99D\uB7C9\uD560 \uC218 \uC788\uC73C\uBA70, \uD658\uC790\uC758 \uC0C1\uD0DC\uB97C \uAD00\uCC30\uD558\uBA74\uC11C \uC2E0\uC911\uD788 \uD22C\uC5EC\uD55C\uB2E4.brbr<P><\/P>2. \uB9CC\uC131 \uC548\uC815\uD611\uC2EC\uC99Dbrbr<P><\/P>1) \uCC98\uC74C \uC774\uD2C0\uC740 \uCE74\uB974\uBCA0\uB51C\uB864\uB85C\uC11C 1\uC77C 1\uD68C, 1\uD68C 32mg\uC744 \uD22C\uC5EC\uD558\uACE0, \uC774 \uD6C4 1\uC77C 1\uD68C, 1\uD68C 64mg\uC744 \uD22C\uC5EC\uD55C\uB2E4.brbr<P><\/P>2) \uD1B5\uC0C1 1\uC77C 1\uD68C, 1\uD68C 64mg\uC744 2\uC8FC\uAC04 \uD22C\uC5EC\uD558\uBA70 \uC99D\uB7C9\uC774 \uD544\uC694\uD55C \uACBD\uC6B0(\uACE0\uB839\uC790\uB294 \uC81C\uC678) 1\uC77C 1\uD68C, 1\uD68C 128mg\uC744 \uD22C\uC5EC\uD55C\uB2E4.brbr<P><\/P>3. \uC6B8\uD608\uC2EC\uBD80\uC804brbr<P><\/P>1) \uC77C\uBC18\uC801\uC73C\uB85C \uCD08\uAE30\uCE58\uB8CC\uC5D0\uB294 \uCE74\uB974\uBCA0\uB51C\uB864\uB85C\uC11C 1\uC77C 1\uD68C, 1\uD68C 8mg\uC744 2\uC8FC\uAC04 \uD22C\uC5EC\uD55C\uB2E4. \uD658\uC790\uAC00 \uC774 \uCE58\uB8CC\uC5D0 \uC798 \uACAC\uB514\uBA74 1\uC77C 1\uD68C, 1\uD68C 16mg\uB85C \uC99D\uB7C9\uD558\uC5EC 2\uC8FC\uAC04 \uD22C\uC5EC\uD55C \uD6C4 1\uC77C 1\uD68C, 1\uD68C 32mg\uB85C \uC99D\uB7C9\uD558\uC5EC 2\uC8FC\uAC04 \uD22C\uC5EC\uD558\uACE0 1\uC77C 1\uD68C, 1\uD68C 64mg\uB85C \uC99D\uB7C9\uD55C\uB2E4.brbr<P><\/P>2) \uAC01 \uC6A9\uB7C9\uB9C8\uB2E4 \uCD5C\uC18C\uD55C 2\uC8FC \uC774\uC0C1 \uBCF5\uC6A9\uD55C \uD6C4 \uC810\uCC28\uC801\uC73C\uB85C \uC99D\uB7C9\uD558\uBA70 \uD658\uC790\uAC00 \uACAC\uB51C \uC218 \uC788\uB294 \uCD5C\uB300 \uC6A9\uB7C9\uAE4C\uC9C0 \uC99D\uB7C9\uD55C\uB2E4.brbr<P><\/P>3) \uC774 \uC57D\uC758 \uC720\uD6A8\uD55C \uCD5C\uC18C\uC6A9\uB7C9\uC740 1\uC77C 1\uD68C, 1\uD68C 16mg\uC774\uBA70 \uCD5C\uB300\uC6A9\uB7C9\uC740 \uCCB4\uC911\uC774 85kg \uC774\uD558\uC778 \uD658\uC790\uB294 1\uC77C 1\uD68C, 1\uD68C 64mg, 85kg \uC774\uC0C1\uC778 \uD658\uC790\uB294 1\uC77C 1\uD68C, 1\uD68C 128mg \uC774\uB2E4.brbr<P><\/P>4. \uC2EC\uBC29\uC138\uB3D9 \uD658\uC790\uC5D0\uC11C\uC758 \uC2EC\uBC15\uC218 \uC870\uC808brbr<P><\/P>\uC774 \uC57D\uC73C\uB85C\uC11C 1\uC77C 1\uD68C 8mg\uC744 \uD22C\uC5EC\uD55C\uB2E4. 2\uC8FC \uD22C\uC5EC \uD6C4 \uD6A8\uACFC\uAC00 \uBD88\uCDA9\uBD84\uD55C \uACBD\uC6B0\uC5D0\uB294 1\uC77C 1\uD68C 16mg\uC744 \uD22C\uC5EC\uD55C\uB2E4. 2\uC8FC \uD22C\uC5EC \uD6C4 \uD6A8\uACFC\uAC00 \uBD88\uCDA9\uBD84\uD560 \uACBD\uC6B0 1\uC77C 1\uD68C 32mg\uC744 \uD22C\uC5EC\uD55C\uB2E4.brbr<P><\/P>","caution":"1. \uB2E4\uC74C \uD658\uC790\uC5D0\uB294 \uD22C\uC5EC\uD558\uC9C0 \uB9D0 \uAC83\r\n<P><\/P>1)\uC774 \uC57D \uB610\uB294 \uC774 \uC57D\uC758 \uAD6C\uC131\uC131\uBD84\uC5D0 \uACFC\uBBFC\uBC18\uC751 \uBCD1\uB825 \uD658\uC790\r\n<P><\/P>2)\uC2EC\uC7A5\uC131\uC1FC\uD06C \uD658\uC790(\uC21C\uD658 \uBD80\uC804\uC99D\uC774 \uC545\uD654\uB420 \uC6B0\uB824\uAC00 \uC788\uB2E4.)\r\n<P><\/P>3)\uC911\uC99D\uC758 \uC11C\uB9E5(50\uD68C\/\uBD84 \uBBF8\uB9CC), \uBC29\uC2E4\uCC28\uB2E8(2, 3\uB3C4), \uB3D9\uBC29\uCC28\uB2E8, \uB3D9\uAE30\uB2A5\uBD80\uC804\uC99D\uD6C4\uAD70(sick-sinus syndrome) \uB4F1 \uC2EC\uC7A5\uC804\uB3C4\uAC00 \uD2B9\uD788 \uD765\uBD84\uB418\uC5B4 \uC788\uAC70\uB098 \uCC28\uB2E8\uB41C \uD658\uC790\r\n<P><\/P>4)\uD3D0\uC2EC\uC7A5\uC99D(Cor pulmonale)\uD658\uC790 (\uD3D0\uACE0\uD608\uC555\uC5D0 \uC758\uD55C \uC6B0\uC2EC\uBD80\uC804\uC774 \uC788\uB294 \uD658\uC790\uC5D0\uC11C \uC2EC\uBC15\uCD9C\uB7C9\uC774 \uC5B5\uC81C\uB418\uC5B4 \uC99D\uC0C1\uC774 \uC545\uD654\uB420 \uC6B0\uB824\uAC00 \uC788\uB2E4.)\r\n<P><\/P>5)\uB2F9\uB1E8\uBCD1\uC5D0 \uC758\uD55C \uCF00\uD1A4\uC0B0\uC99D, \uB300\uC0AC\uC0B0\uC99D \uD658\uC790(\uC2EC\uADFC \uC218\uCD95\uB825 \uC5B5\uC81C\uC791\uC6A9\uC774 \uCEE4\uC9C8 \uC218 \uC788\uB2E4.)\r\n<P><\/P>6)NYHA (New York Heart Association) Class IV\uC758 \uC2EC\uAE30\uB2A5 \uBCF4\uC0C1\uAE30\uC804\uC0C1\uC2E4 \uD658\uC790 \uB4F1 \uC2EC\uADFC\uB825\uC774 \uC1E0\uC57D\uD55C \uC790 \uD639\uC740 \uBD88\uC548\uC815\uC2EC\uBD80\uC804 \uD658\uC790\r\n<P><\/P>7)\uCC9C\uC2DD\uD658\uC790, \uB9CC\uC131\uD3D0\uC1C4 \uD3D0\uC9C8\uD658 \uB4F1 \uAE30\uAD00\uC9C0 \uACBD\uB828\uC774 \uC788\uB294 \uD638\uD761\uAE30 \uC9C8\uD658\uC790 \uD639\uC740 \uADF8 \uBCD1\uB825 \uD658\uC790(\uAE30\uAD00\uC9C0 \uADFC\uC721\uC744 \uC218\uCD95\uC2DC\uD0AC \uC218 \uC788\uC73C\uBBC0\uB85C \uC99D\uC0C1\uC744 \uC720\uBC1C, \uC545\uD654\uC2DC\uD0AC \uC218 \uC788\uB2E4. \uC77C\uBC18 \uC815\uC81C\uC5D0\uC11C \uCC9C\uC2DD\uC9C0\uC18D\uC0C1\uD0DC\uC5D0 \uC758\uD55C \uC0AC\uB9DD\uC774 \uBCF4\uACE0\uB41C \uBC14 \uC788\uB2E4.)\r\n<P><\/P>8)\uC774\uCC28\uACE0\uD608\uC555 \uD658\uC790\r\n<P><\/P>9)\uD504\uB9B0\uCE20\uBA54\uD0C8\uD611\uC2EC\uC99D \uD658\uC790(\uD749\uD1B5\uC744 \uC720\uBC1C\uD560 \uC218 \uC788\uB2E4.)\r\n<P><\/P>10)\uAE09\uC131 \uD3D0\uB3D9\uB9E5 \uC0C9\uC804\uC99D \uD658\uC790\r\n<P><\/P>11)\uD06C\uB86C\uCE5C\uD654\uC138\uD3EC\uC885 \uD658\uC790(\uC774 \uC57D\uC758 \uB2E8\uB3C5\uD22C\uC5EC\uC5D0 \uC758\uD574 \uAE09\uACA9\uD558\uAC8C \uD608\uC555\uC774 \uC0C1\uC2B9\uD560 \uC6B0\uB824\uAC00 \uC788\uB2E4.)\r\n<P><\/P>12)MAO \uC5B5\uC81C\uC81C \uBCF5\uC6A9\uC790(MAO-B \uC5B5\uC81C\uC81C \uC81C\uC678)\r\n<P><\/P>13)\uC218\uCD95\uAE30 \uD608\uC555 90 mmHg \uC774\uD558\uC758 \uC2EC\uD55C \uC800\uD608\uC555 \uD658\uC790\r\n<P><\/P>14)\uC911\uC99D \uAC04\uAE30\uB2A5 \uC190\uC0C1 \uD658\uC790\r\n<P><\/P>15)\uC784\uBD80 \uB610\uB294 \uC784\uC2E0\uD558\uACE0 \uC788\uC744 \uAC00\uB2A5\uC131\uC774 \uC788\uB294 \uC5EC\uC131 \uBC0F \uC218\uC720\uBD80\r\n<P><\/P>16)\uB9D0\uCD08\uC21C\uD658\uC7A5\uC560(\uC608, \uB808\uC774\uB178\uC99D\uD6C4\uAD70, \uAC04\uD5D0\uD30C\uD589 \uB4F1) \uD658\uC790 (\uB9D0\uCD08\uD608\uAD00\uD655\uC7A5\uC744 \uC5B5\uC81C\uD558\uACE0 \uD608\uB958\uC7A5\uC560\uC99D\uC0C1\uC744 \uC545\uD654\uC2DC\uD0AC \uC218 \uC788\uB2E4.)\r\n<P><\/P>17)\uC131\uBB38\uBD80\uC885 \uD658\uC790\r\n<P><\/P>18)\uD569\uBCD1\uC99D\uC744 \uB3D9\uBC18\uD55C \uC2EC\uC7A5\uBC1C\uC791 \uD658\uC790\r\n<P><\/P>19)\uC815\uB9E5\uB0B4 \uADFC\uC721\uC218\uCD95\uC81C\uB97C \uD544\uC694\uB85C \uD558\uB294 \uD604\uC800\uD55C \uCCB4\uC561\uC800\uB958 \uD658\uC790 \uD639\uC740 \uACFC\uBD80\uD558 \uD658\uC790\r\n<P><\/P>20)\uC54C\uB808\uB974\uAE30 \uBE44\uC5FC \uD658\uC790\r\n<P><\/P>2. \uB2E4\uC74C \uD658\uC790\uC5D0\uB294 \uC2E0\uC911\uD788 \uD22C\uC5EC\uD560 \uAC83\r\n<P><\/P>1) \uB2F9\uB1E8\uBCD1 \uD658\uC790\r\n<P><\/P>2)\uC2EC\uD55C \uACFC\uBBFC\uBC18\uC751 \uBCD1\uB825\uC790\uB098 \uBBFC\uAC10\uC131\uC744 \uC904\uC774\uB294 \uCE58\uB8CC\uB97C \uBC1B\uB294(hyposensitization therapy) \uD658\uC790(\uBCA0\uD0C0\uCC28\uB2E8\uC81C\uB294 \uC54C\uB808\uB974\uAE30\uD56D\uC6D0\uC5D0 \uB300\uD55C \uBBFC\uAC10\uC131\uACFC \uACFC\uBBFC\uBC18\uC751\uC744 \uC99D\uAC00\uC2DC\uD0A8\uB2E4.)\r\n<P><\/P>3)\uBCA0\uD0C0\uCC28\uB2E8\uC81C\uC5D0 \uC758\uD55C \uAC74\uC120 \uBCD1\uB825\uC774 \uC788\uB294 \uD658\uC790 \uB610\uB294 \uC774\uB7EC\uD55C \uAC00\uC871\uB825\uC774 \uC788\uB294 \uD658\uC790\r\n<P><\/P>4)\uC800\uD608\uC555(\uC218\uCD95\uAE30\uD608\uC555 100 mmHg \uC774\uD558)\uACFC \uD568\uAED8 \uD5C8\uD608\uC2EC\uC9C8\uD658\uC758 \uBC94\uBC1C\uC131 \uD608\uAD00\uC9C8\uD658, \uB610\uB294 \uC2E0\uAE30\uB2A5 \uBD80\uC804 \uB4F1\uC774 \uC788\uB294 \uD658\uC790(\uC774 \uC57D\uC744 \uD22C\uC5EC\uC2DC \uAC00\uC5ED\uC801\uC778 \uC2E0\uAE30\uB2A5 \uC7A5\uC560\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.)\r\n<P><\/P>5)\uBD88\uC548\uC815\uD611\uC2EC\uC99D\uD658\uC790(\uC784\uC0C1\uACBD\uD5D8\uC774 \uC801\uC73C\uBBC0\uB85C \uC774\uB7EC\uD55C \uC9D5\uD6C4\uB098 \uC99D\uC0C1\uC744 \uBCF4\uC774\uB294 \uD658\uC790\uC5D0\uAC8C \uC774 \uC57D\uC744 \uD22C\uC5EC\uC2DC \uC8FC\uC758\uD55C\uB2E4.)\r\n<P><\/P>6)\uB9CC\uC131 \uC6B8\uD608\uC2EC\uBD80\uC804 \uD658\uC790(\uC6B8\uD608\uC2EC\uBD80\uC804 \uD658\uC790\uC5D0\uAC8C \uC774 \uC57D\uC744 \uC99D\uB7C9\uD560 \uB54C \uC2EC\uBD80\uC804\uC774 \uC545\uD654\uB418\uAC70\uB098 \uCCB4\uC561 \uC800\uB958\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.)\r\n<P><\/P>7)\uC911\uC99D\uC758 \uC2E0\uC7A5\uC560 \uD658\uC790(\uC774 \uC57D\uC758 \uD608\uC911\uB18D\uB3C4 \uC99D\uAC00\uAC00 \uBCF4\uACE0\uB41C \uBC14 \uC788\uB2E4.)\r\n<P><\/P>8)1\uB3C4 \uBC29\uC2E4\uCC28\uB2E8 \uD658\uC790(\uBC29\uC2E4\uC804\uB3C4 \uC2DC\uAC04\uC774 \uC5F0\uC7A5\uB418\uACE0 \uC99D\uC0C1\uC744 \uC545\uD654\uC2DC\uD0AC \uC6B0\uB824\uAC00 \uC788\uB2E4.)\r\n<P><\/P>9) \uACBD\uC99D\uC5D0\uC11C \uC911\uB4F1\uB3C4 \uC11C\uB9E5\uD658\uC790\r\n<P><\/P>10) \uC548\uC57D\uD615\uD0DC\uC758 \uBCA0\uD0C0\uCC28\uB2E8\uC81C \uD22C\uC5EC\uC911\uC778 \uD658\uC790\r\n<P><\/P>11) \uACE0\uB839\uC790\r\n<P><\/P>12) \uC790\uC138\uBCC0\uD654\uC2DC \uD608\uC555\uAC15\uD558\uD558\uB294 \uACBD\uD5A5\uC774 \uC788\uB294 \uD658\uC790\r\n<P><\/P>13) \uAE09\uC131 \uC5FC\uC99D\uC131 \uC2EC\uC7A5\uBCD1, \uC2EC\uC7A5\uD310\uB9C9 \uD639\uC740 \uC2EC\uD608\uAD00\uC758 \uBCC0\uD654 \uD658\uC790\r\n<P><\/P>14) \u03B11-\uC218\uC6A9\uCCB4 \uAE38\uD56D\uC81C \uD639\uC740 \u03B12\u2013\uC218\uC6A9\uCCB4 \uC791\uC6A9\uC81C\uC640 \uBCD1\uC6A9\uD558\uB294 \uD658\uC790\r\n<P><\/P>15)\uC5FC\uBD84 \uD639\uC740 \uC218\uBD84 \uACB0\uD54D \uD658\uC790(\uC608, \uACE0\uC6A9\uB7C9\uC758 \uC774\uB1E8\uC81C \uD22C\uC5EC)\r\n<P><\/P>16)\uAC15\uC2EC\uBC30\uB2F9\uCCB4 \uB3D9\uC2DC \uD22C\uC5EC\uC911\uC778 \uD658\uC790\r\n<P><\/P>17)\uBCA0\uB77C\uD30C\uBC00, \uB51C\uD2F0\uC544\uC82C \uB4F1 \uBE44-\uB514\uD558\uC774\uB4DC\uB85C\uD53C\uB9AC\uB518\uACC4 \uCE7C\uC298\uCC44\uB110\uCC28\uB2E8\uC81C \uD639\uC740 \uD56D\uBD80\uC815\uB9E5\uC81C \uB3D9\uC2DC \uBCF5\uC6A9\uC911\uC778 \uD658\uC790\r\n<P><\/P>18) \uAE08\uC2DD \uD658\uC790\r\n<P><\/P>19) \uAC11\uC0C1\uC0D8\uAE30\uB2A5\uD56D\uC9C4\uD658\uC790\r\n<P><\/P>20) \uCF58\uD0DD\uD2B8\uB80C\uC988 \uC0AC\uC6A9 \uD658\uC790\r\n<P><\/P>21) 18\uC138 \uBBF8\uB9CC\uC758 \uC18C\uC544 \uBC0F \uCCAD\uC18C\uB144\r\n<P><\/P>22) \uAE09\uC131\uC2EC\uADFC\uACBD\uC0C9 \uBC1C\uBCD1\uD658\uC790 \uC911 \uD608\uC5ED\uD559\uC801 \uBD88\uC548\uC815 \uD658\uC790\r\n<P><\/P>23) \uAD00\uC0C1\uB3D9\uB9E5\uC2EC\uC7A5\uC9C8\uD658\uC774 \uC788\uB294 \uACE0\uD608\uC555 \uD658\uC790\r\n<P><\/P>3. \uC774\uC0C1\uBC18\uC751\r\n<P><\/P>1)\uC911\uCD94\uC2E0\uACBD\uACC4: \uB54C\uB54C\uB85C \uC5B4\uC9C0\uB7FC, \uB450\uD1B5, \uD53C\uB85C, \uB4DC\uBB3C\uAC8C \uBB34\uB825\uC774 \uB098\uD0C0\uB098\uB294\uB370 \uC774\uB7F0 \uC99D\uC0C1\uC740 \uBCF4\uD1B5 \uACBD\uC99D\uC774\uBA70 \uD2B9\uD788 \uCE58\uB8CC\uCD08\uAE30\uC5D0 \uBC1C\uC0DD\uD55C\uB2E4. \uB4DC\uBB3C\uAC8C \uD658\uAC01, \uCC29\uB780, \uC6B0\uC6B8, \uC218\uBA74\uC7A5\uC560, \uC545\uBABD, \uC815\uC2E0\uBCD1 \uB4F1\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>2)\uC2EC\uD608\uAD00\uACC4\r\n<P><\/P>(1) \uACE0\uB3C4\uC758 \uC11C\uB9E5,\uC1FC\uD06C, \uC644\uC804\uD55C \uBC29\uC2E4\uCC28\uB2E8, \uC2EC\uBD80\uC804(\uAE09\uC131\uC744 \uD3EC\uD568), \uC2EC\uC7A5\uC815\uC9C0 \uB4F1\uACFC \uAC19\uC740 \uC911\uB300\uD55C \uC774\uC0C1\uBC18\uC751\uC774 \uC77C\uC5B4\uB0A0 \uC218 \uC788\uC73C\uBBC0\uB85C \uC2EC\uAE30\uB2A5\uAC80\uC0AC\uB97C \uC815\uAE30\uC801\uC73C\uB85C \uC2E4\uC2DC\uD558\uACE0 \uADF8\uB7EC\uD55C \uC99D\uC0C1\uC774 \uB098\uD0C0\uB098\uBA74 \uAC10\uB7C9 \uB610\uB294 \uD22C\uC5EC\uC911\uC9C0 \uB4F1 \uC801\uC808\uD55C \uC870\uCE58\uB97C \uCDE8\uD55C\uB2E4.\r\n<P><\/P>(2) \uB54C\uB54C\uB85C,\uD2B9\uD788 \uC774 \uC57D\uC744 \uCC98\uC74C \uBCF5\uC6A9\uD558\uAC70\uB098 \uC99D\uB7C9\uD560 \uB54C \uB610\uB294 \uAC11\uC790\uAE30 \uC77C\uC5B4\uC124 \uB54C \uC5B4\uC9C0\uB7FC, \uB208\uC55E\uC774 \uCE84\uCE84\uD568 \uB4F1\uC758 \uC99D\uC0C1\uACFC \uD568\uAED8 \uD608\uC555\uC774 \uD604\uC800\uD788 \uB0AE\uC544\uC9C8 \uC218 \uC788\uC73C\uBA70, \uB4DC\uBB3C\uAC8C \uC758\uC2DD\uC744 \uC0C1\uC2E4\uD560 \uC218 \uC788\uB2E4.\r\n<P><\/P>(3)\uB54C\uB54C\uB85C \uB9E5\uBC15\uC218\uAC00 \uAC10\uC18C\uD560 \uC218 \uC788\uC73C\uBA70, \uB4DC\uBB3C\uAC8C \uC0AC\uC9C0\uB0C9\uAC10\uC774 \uB098\uD0C0\uB09C\uB2E4. \uC774\uB7EC\uD55C \uC99D\uC0C1\uC740 \uAC04\uD5D0\uD30C\uD589, \uB808\uC774\uB178\uBCD1, \uD611\uC2EC\uC99D, \uBD80\uC885 \uD658\uC790\uC758 \uACBD\uC6B0 \uC545\uD654\uB420 \uC218 \uC788\uB2E4.\r\n<P><\/P>(4)\uC2EC\uBD80\uC804 \uD658\uC790\uB294 \uC5B4\uC9C0\uB7FC\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uACE0, \uB54C\uB54C\uB85C \uB2E4\uC591\uD55C \uBCD1\uC18C\uC640 \uD06C\uAE30\uC758 \uBD80\uC885\uC774, \uB4DC\uBB3C\uAC8C(\uD2B9\uD788 \uC6A9\uB7C9 \uC99D\uAC00\uC2DC) \uBC29\uC2E4\uCC28\uB2E8, \uC2EC\uBD80\uC804\uC758 \uC545\uD654\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>3) \uC2E0\uC7A5:\uC804\uC2E0\uC801\uC778 \uD608\uAD00\uC7A5\uC560\uAC00 \uC788\uAC70\uB098 \uC2E0\uAE30\uB2A5\uC774 \uC190\uC0C1\uB41C \uC790\uB294 \uC2E0\uAE30\uB2A5\uC774 \uC545\uD654\uB418\uAC70\uB098 \uB4DC\uBB3C\uAC8C \uC2E0\uBD80\uC804\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>4) \uD638\uD761\uAE30\uACC4:\uD638\uD761\uAE30\uB3C4\uC758 \uC800\uD56D\uC131\uC774 \uC99D\uAC00\uB420 \uC218 \uC788\uB2E4.\r\n<P><\/P>5) \uC18C\uD654\uAE30\uACC4:\uB54C\uB54C\uB85C \uAD6C\uC5ED, \uC124\uC0AC, \uBCF5\uD1B5, \uAD6C\uD1A0\uAC00 \uB4DC\uBB3C\uAC8C \uBCC0\uBE44\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>6) \uD53C\uBD80:\uB450\uB4DC\uB7EC\uAE30, \uAC00\uB824\uC6C0, \uD3B8\uD3C9\uD0DC\uC120 \uC720\uC0AC\uBC18\uC751(lichen planus-like reaction) \uB4F1\uC774 \uBCF4\uACE0\uB418\uC5C8\uC73C\uBA70, \uB4DC\uBB3C\uAC8C \uC54C\uB808\uB974\uAE30 \uBC1C\uC9C4\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4. \uBCA0\uD0C0\uCC28\uB2E8\uC791\uC6A9\uC744 \uAC00\uC9C0\uB294 \uC57D\uBB3C\uC740 \uC2EC\uC0C1\uC131 \uAC74\uC120\uC744 \uC720\uBC1C\uD558\uAC70\uB098, \uC774 \uC9C8\uBCD1\uC758 \uC99D\uC0C1\uC744 \uC545\uD654\uC2DC\uD0A4\uAC70\uB098, \uAC74\uC120\uC591 \uBC1C\uC9C4\uC744 \uB098\uD0C0\uB0BC \uC218 \uC788\uB2E4.\r\n<P><\/P>7)\uD608\uC561\uACC4: \uD608\uCCAD \uC544\uBBF8\uB178\uC804\uB2EC\uD6A8\uC18C \uB4F1 \uAC04\uAE30\uB2A5\uC9C0\uD45C\uC758 \uBCC0\uD654, \uD608\uC18C\uD310\uAC10\uC18C\uC99D, \uBC31\uD608\uAD6C\uAC10\uC18C\uC99D\uC774 \uB4DC\uBB3C\uAC8C \uBCF4\uACE0\uB418\uC5C8\uB2E4.\r\n<P><\/P>8)\uB0B4\uBD84\uBE44\uACC4: \uBCA0\uD0C0\uCC28\uB2E8\uC81C\uC758 \uD2B9\uC131\uC0C1 \uC7A0\uBCF5\uAE30\uC758 \uB2F9\uB1E8\uBCD1\uC774 \uBC1C\uD604\uB420 \uC218 \uC788\uC73C\uBA70, \uBC1C\uD604\uB41C \uC99D\uC0C1\uC774 \uC545\uD654\uB418\uAC70\uB098 \uD608\uB2F9\uC870\uC808\uC774 \uC5B5\uC81C\uB420 \uC218 \uC788\uACE0 \uC800\uD608\uB2F9\uC774\uB098 \uAC11\uC0C1\uC120\uC758 \uACFC\uB2E4\uAE30\uB2A5(\uB192\uC740 \uC2EC\uBC15\uC218 \uB4F1)\uC774 \uC740\uD3D0\uB420 \uC218 \uC788\uB2E4. \uC2EC\uAE30\uB2A5\uBD80\uC804\uD658\uC790\uB294 \uACE0\uD608\uB2F9, \uCCB4\uC911\uC99D\uAC00, \uD608\uC911 \uCF5C\uB808\uC2A4\uD14C\uB864\uCE58\uC758 \uC99D\uAC00(\uC774\uBBF8 \uB2F9\uB1E8\uBCD1\uC744 \uC553\uACE0 \uC788\uB294 \uACBD\uC6B0)\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>9)\uC21C\uD658\uAE30\uACC4: \uC11C\uB9E5, \uC800\uD608\uC555, \uC228\uCC38, \uC5B4\uC9C0\uB7FC\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uACE0(0.1~5% \uBBF8\uB9CC), \uB4DC\uBB3C\uAC8C \uD611\uC2EC\uC99D \uD658\uC790\uC5D0\uC11C \uACE0\uD608\uC555\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>10)\uAC04\uC7A5: AST, ALT, \u03B3-GTP\uC758 \uC0C1\uC2B9 \uB4F1\uC744 \uC218\uBC18\uD558\uB294 \uAC04\uAE30\uB2A5\uC7A5\uC560 \uBC0F \uD669\uB2EC\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4. \uAC04\uAE30\uB2A5\uC7A5\uC560 \uC99D\uC0C1(\uC608, \uC9D9\uC740 \uC18C\uBCC0\uC0C9, \uC9C0\uC18D\uC801 \uC2DD\uC695\uBD80\uC9C4, \uD669\uB2EC, \uC624\uB978\uCABD \uC0C1\uBD80\uC758 \uC555\uBC15 \uD1B5\uC99D, \uC124\uBA85\uD560 \uC218 \uC5C6\uB294 \uB3C5\uAC10\uC99D\uC138 \uB4F1)\uC774 \uB098\uD0C0\uB098\uBA74, \uC2E0\uC911\uD788 \uAC80\uC0AC\uD574\uC57C \uD558\uBA70 \uAC04\uC190\uC0C1\uC774\uB098 \uD669\uB2EC\uC774 \uD655\uC2E4\uD558\uB2E4\uBA74 \uC774 \uC57D\uC758 \uC0AC\uC6A9\uC744 \uC911\uB2E8\uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>11)\uAE30\uD0C0: \uB54C\uB54C\uB85C \uC0AC\uC9C0\uC758 \uD1B5\uC99D, \uB208\uBB3C\uAC10\uC18C, \uB4DC\uBB3C\uAC8C \uAC10\uAC01\uC7A5\uC560(\uCC29\uAC10\uAC01\uC99D, \uAC10\uAC01\uC774\uC0C1), \uC2DC\uAC01\uC7A5\uC560, \uB208\uC758 \uC790\uADF9, \uAD6C\uAC15\uAC74\uC870, \uBC30\uB1E8\uC7A5\uC560(\uC694\uC2E4\uAE08 \uD3EC\uD568), \uC131\uAE30\uB2A5\uC7A5\uC560, \uC54C\uB808\uB974\uAE30 \uBC18\uC751\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>12)\uAD6D\uB0B4 \uC2DC\uD310\uD6C4 \uC870\uC0AC\uACB0\uACFC(\uC6B8\uD608\uC2EC\uBD80\uC804: 721\uB840, \uB9CC\uC131\uC548\uC815\uD611\uC2EC\uC99D: 661\uB840) \uBCF4\uACE0\uB41C \uC774\uC0C1\uBC18\uC751: \uB2E4\uC74C \uC774\uC0C1\uBC18\uC751 \uBAA8\uB450 0.1% \uBBF8\uB9CC\uC73C\uB85C \uB4DC\uBB3C\uAC8C \uBC1C\uD604\uB418\uC5C8\uC73C\uBA70, \uC774 \uC57D\uACFC\uC758 \uAD00\uB828 \uC5EC\uBD80\uB294 \uD655\uC2E4\uD558\uC9C0 \uC54A\uB2E4.\r\n<P><\/P>(1) \uC6B8\uD608\uC2EC\uBD80\uC804:\uB1CC\uD608\uAD00\uC7A5\uC560, \uAC1D\uB2F4\uC99D\uAC00, \uBE48\uB9E5, \uACFC\uD608\uB2F9\uC99D, \uD64D\uC870, \uBC31\uD608\uAD6C\uC99D\uAC00\uC99D, \uD608\uB1E8\r\n<P><\/P>(2) \uB9CC\uC131\uC548\uC815\uD611\uC2EC\uC99D: \uC2EC\uADFC\uACBD\uC0C9, \uACE0\uCE7C\uB968\uD608\uC99D\r\n<P><\/P>13) \uAD6D\uB0B4\uBCF8\uD0DC\uC131\uACE0\uD608\uC555 \uD658\uC790 238\uBA85\uC744 \uB300\uC0C1\uC73C\uB85C \uC774 \uC57D\uC744 8\uC8FC\uAC04 \uD22C\uC5EC\uD55C \uBB34\uC791\uC704\uBC30\uC815, \uD65C\uC131\uB300\uC870(\uCE74\uB974\uBCA0\uB51C\uB864 \uC77C\uBC18\uC815) \uC784\uC0C1\uC2DC\uD5D8\uC5D0\uC11C \uC774\uC0C1\uBC18\uC751\uC740 \uCD1D 42\uBA85(17.65%, 62\uAC74)\uC5D0\uC11C \uBC1C\uC0DD\uD558\uC600\uB2E4. \uC774 \uC911 \uC774 \uC57D \uD22C\uC5EC\uAD70\uC740 18\uBA85(14.88%, 24\uAC74), \uB300\uC870\uC57D \uD22C\uC5EC\uAD70\uC740 24\uBA85(20.51%, 38\uAC74)\uC5D0\uC11C \uBC1C\uC0DD\uD558\uC600\uACE0, \uD22C\uC5EC\uAD70\uAC04 \uC720\uC758\uD55C \uCC28\uC774\uB294 \uC5C6\uC5C8\uB2E4. \uBCF4\uACE0\uB41C \uC774\uC0C1\uBC18\uC751\uC740 \uB300\uBD80\uBD84 \uACBD\uC99D \uBC0F \uC911\uB4F1\uC99D\uC774\uC5C8\uB2E4. 1% \uC774\uC0C1\uC758 \uBE48\uB3C4\uB85C \uBCF4\uACE0\uB41C \uC774\uC0C1\uBC18\uC751\uC740 \uC774 \uC57D \uD22C\uC5EC\uAD70\uC5D0\uC11C \uC911\uC131\uC9C0\uBC29\uC99D\uAC00(2.48%, 3\uAC74), \uB450\uD1B5(1.65%, 3\uAC74), \uC124\uC0AC(1.65%, 2\uAC74)\uC774\uC5C8\uACE0, \uB300\uC870\uC57D \uD22C\uC5EC\uAD70\uC5D0\uC11C \uC5B4\uC9C0\uB7EC\uC6C0(3.42%, 4\uAC74), \uD608\uB2F9\uC99D\uAC00(1.71%, 2\uAC74)\uC774\uC5C8\uB2E4. \uC911\uB300\uD55C \uC774\uC0C1\uBC18\uC751\uC740 \uCD1D 5\uAC74(\uC5BC\uAD74\uB9C8\uBE44, \uC790\uAD81\uC12C\uC720\uC885, \uAC70\uBBF8\uB9C9\uD558\uCD9C\uD608, \uAC08\uBE44\uBF08\uACE8\uC808, \uB2E4\uB9AC\uACE8\uC808)\uC774\uC5C8\uACE0, \uBAA8\uB450 \uC2DC\uD5D8\uC57D\uACFC \uAD00\uB828\uC774 \uC5C6\uB294 \uAC83\uC73C\uB85C \uD310\uB2E8\uB418\uC5C8\uB2E4. \uC2DC\uD5D8\uC57D\uACFC\uC758 \uC778\uACFC\uAD00\uACC4\uB97C \uBC30\uC81C\uD560 \uC218 \uC5C6\uB294 \uC774\uC0C1\uC57D\uBB3C\uBC18\uC751\uC740 \uCD1D 6\uBA85(2.52%, 8\uAC74)\uC5D0\uC11C \uBCF4\uACE0\uB418\uC5C8\uACE0, \uC544\uB798 \uD45C\uC5D0 \uBC1C\uD604\uAE30\uAD00\uBCC4\uB85C \uAD6C\uBD84\uD558\uC5EC \uB098\uD0C0\uB0B4\uC5C8\uB2E4. \uBCF4\uACE0\uB41C \uC57D\uBB3C\uC774\uC0C1\uBC18\uC751\uC740 \uBAA8\uB450 \uACBD\uC99D\uC774\uC5C8\uB2E4.\r\n<P><\/P>[\uD45C] \uC774 \uC57D\uACFC\uC758 \uC778\uACFC\uAD00\uACC4\uB97C \uBC30\uC81C\uD560 \uC218 \uC5C6\uB294 \uC774\uC0C1\uC57D\uBB3C \uBC18\uC751 \uBC1C\uD604\uC728\r\n<P><\/P>\r\n[&C1]14) \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131\uC81C\uC81C\uC758\uAD6D\uB0B4 \uC2DC\uD310 \uD6C4 \uC870\uC0AC\uACB0\uACFC\r\n<P><\/P>\uAD6D\uB0B4\uC5D0\uC11C \uC7AC\uC2EC\uC0AC\uB97C \uC704\uD558\uC5EC 6\uB144 \uB3D9\uC548 \uBCF8\uD0DC\uC131 \uACE0\uD608\uC555 \uD658\uC790 684\uBA85\uC744 \uB300\uC0C1\uC73C\uB85C \uC2E4\uC2DC\uD55C \uC2DC\uD310 \uD6C4 \uC870\uC0AC \uACB0\uACFC, \uC774\uC0C1\uC0AC\uB840\uC758 \uBC1C\uD604\uC728\uC740 \uC778\uACFC\uAD00\uACC4\uC640 \uC0C1\uAD00\uC5C6\uC774 12.43%(85\/684\uBA85, 99\uAC74)\uB85C \uBCF4\uACE0\uB418\uC5C8\uB2E4. \uC774 \uC911 \uC778\uACFC\uAD00\uACC4\uC640 \uC0C1\uAD00\uC5C6\uB294 \uC911\uB300\uD55C \uC774\uC0C1\uC0AC\uB840\uB97C \uBC1C\uD604 \uBE48\uB3C4\uC5D0 \uB530\uB77C \uC544\uB798 \uD45C\uC5D0 \uB098\uC5F4\uD558\uC600\uC73C\uBA70, \uC778\uACFC\uAD00\uACC4\uB97C \uBC30\uC81C\uD560 \uC218 \uC5C6\uB294 \uC911\uB300\uD55C \uC57D\uBB3C\uC774\uC0C1\uBC18\uC751\uC740 \uBCF4\uACE0\uB418\uC9C0 \uC54A\uC558\uB2E4.\r\n<P><\/P>\r\n[&C2]\uB610\uD55C, \uC778\uACFC\uAD00\uACC4\uC640 \uC0C1\uAD00\uC5C6\uB294 \uC608\uC0C1\uD558\uC9C0 \uBABB\uD55C \uC774\uC0C1\uC0AC\uB840\uC640 \uC778\uACFC\uAD00\uACC4\uB97C \uBC30\uC81C\uD560 \uC218 \uC5C6\uB294 \uC608\uC0C1\uD558\uC9C0 \uBABB\uD55C \uC57D\uBB3C\uC774\uC0C1\uBC18\uC751\uC740 \uBC1C\uD604 \uBE48\uB3C4\uC5D0 \uB530\uB77C \uB2E4\uC74C\uC758 \uD45C\uC5D0 \uB098\uC5F4\uD558\uC600\uB2E4.\r\n<P><\/P>\r\n[&C3]15) \uAD6D\uB0B4 \uC2EC\uBC29\uC138\uB3D9 \uD658\uC790 154\uBA85\uC744 \uB300\uC0C1\uC73C\uB85C \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C 8~32mg\uC744 6\uC8FC\uAC04 \uD22C\uC5EC\uD55C \uBB34\uC791\uC704\uBC30\uC815, \uC704\uC57D\uB300\uC870 \uC784\uC0C1\uC2DC\uD5D8\uC5D0\uC11C \uD22C\uC57D\uAE30(0~6\uC8FC) \uB3D9\uC548 \uC774\uC0C1\uBC18\uC751\uC740 \uCD1D 43\uBA85(27.92%, 60\uAC74)\uC5D0\uC11C \uBC1C\uC0DD\uD558\uC600\uB2E4. \uC774 \uC911 \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C \uD22C\uC5EC\uAD70\uC740 31\uBA85(29.81%, 43\uAC74), \uC704\uC57D \uD22C\uC5EC\uAD70\uC740 12\uBA85(24.00%, 17\uAC74)\uC5D0\uC11C \uBC1C\uC0DD\uD558\uC600\uACE0, \uD22C\uC5EC\uAD70\uAC04 \uC720\uC758\uD55C \uCC28\uC774\uB294 \uC5C6\uC5C8\uB2E4. \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C \uD22C\uC5EC\uAD70\uC758 \uC5F0\uC7A5\uAE30(6~10\uC8FC) \uB3D9\uC548 \uBC1C\uD604\uD55C \uC774\uC0C1\uBC18\uC751\uC740 71\uBA85 \uC911 10\uBA85(14.08%, 15\uAC74)\uC774 \uBCF4\uACE0\uB418\uC5C8\uB2E4.\r\n<P><\/P>[\uD45C] \uD22C\uC57D\uAE30(0~6\uC8FC) \uB3D9\uC548 \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C (n=104)\uC5D0\uC11C \uBC1C\uD604\uB41C \uC774\uC0C1\uBC18\uC751\r\n<P><\/P>\r\n[&C4][\uD45C] \uC5F0\uC7A5\uAE30(6~10\uC8FC) \uB3D9\uC548 \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C(n=71)\uC5D0\uC11C \uBC1C\uD604\uB41C \uC774\uC0C1\uBC18\uC751\r\n<P><\/P>\r\n[&C5]4. \uC77C\uBC18\uC801 \uC8FC\uC758\r\n<P><\/P>1)\uC7A5\uAE30\uD22C\uC5EC\uC2DC\uB294 \uC2EC\uAE30\uB2A5\uAC80\uC0AC(\uB9E5\uBC15, \uD608\uC555, \uC2EC\uC804\uB3C4, X\uC120 \uB4F1)\uB97C \uC815\uAE30\uC801\uC73C\uB85C \uD55C\uB2E4. \uD2B9\uD788 \uC11C\uB9E5 \uBC0F \uC800\uD608\uC555\uC744 \uC77C\uC73C\uD0A8 \uACBD\uC6B0\uC5D0\uB294 \uAC10\uB7C9\uD558\uAC70\uB098 \uD22C\uC5EC\uB97C \uC911\uC9C0\uD55C\uB2E4. \uB610\uD55C \uAC04\uAE30\uB2A5, \uC2E0\uAE30\uB2A5, \uD608\uC561\uC0C1 \uB4F1\uC5D0 \uC8FC\uC758\uD55C\uB2E4.\r\n<P><\/P>2)\uBCA0\uD0C0\uCC28\uB2E8\uC81C(\uD504\uB85C\uD504\uB77C\uB180\uB864\uC5FC\uC0B0\uC5FC)\uC744 \uD22C\uC5EC\uC911\uC778 \uD611\uC2EC\uC99D \uD658\uC790\uB85C\uC11C \uAC11\uC790\uAE30 \uD22C\uC5EC\uB97C \uC911\uC9C0\uD588\uC744 \uB54C \uC99D\uC0C1\uC774 \uC545\uD654\uB418\uAC70\uB098 \uC2EC\uADFC\uACBD\uC0C9\uC744 \uC77C\uC73C\uD0A8 \uC99D\uB840\uAC00 \uBCF4\uACE0\uB418\uC5B4 \uC788\uC73C\uBBC0\uB85C \uD734\uC57D\uC774 \uD544\uC694\uD55C \uACBD\uC6B0\uC5D0\uB294 \uCC9C\uCC9C\uD788 \uAC10\uB7C9\uD558\uBA74\uC11C \uAD00\uCC30\uC744 \uCDA9\uBD84\uD788 \uD55C\uB2E4. \uC758\uC0AC\uC758 \uC9C0\uC2DC\uC5C6\uC774 \uC911\uB2E8\uD558\uC9C0 \uC54A\uC73C\uBA70, \uACE0\uB839\uC790\uC5D0\uAC8C\uC11C \uD2B9\uD788 \uC8FC\uC758\uD55C\uB2E4.\r\n<P><\/P>3)\uC5FC\uB958 \uBC0F(\uB610\uB294) \uCCB4\uC561\uC774 \uBD80\uC871\uD55C \uC790(\uC774\uB1E8\uC81C \uACE0\uC6A9\uB7C9 \uD22C\uC5EC \uB4F1), 70\uC138 \uC774\uC0C1 \uACE0\uB839\uC790, \uCD08\uAE30 \uC218\uCD95\uAE30 \uD608\uC555 100 mmHg\uC774\uD558\uC758 \uC800\uD608\uC555\uD658\uC790\uC5D0\uAC8C \uCC98\uC74C\uD22C\uC5EC\uBC0F \uC6A9\uB7C9\uC99D\uAC00\uC2DC \uD608\uC555\uAC15\uD558\uD6A8\uACFC\uAC00 \uC99D\uD3ED\uB420 \uC218 \uC788\uC73C\uBBC0\uB85C \uD22C\uC5EC \uD6C4 2\uC2DC\uAC04\uAE4C\uC9C0 \uC8FC\uC758\uD558\uC5EC \uAD00\uCC30\uD55C\uB2E4.\r\n<P><\/P>4)\uD074\uB85C\uB2C8\uB518\uACFC \uBCD1\uC6A9\uD22C\uC5EC\uB97C \uC911\uB2E8\uD574\uC57C \uD560 \uB54C\uC5D0\uB294 \uC774 \uC57D\uC744 \uC77C\uB2E8 \uC911\uB2E8\uD55C \uD6C4 \uC218\uC77C\uB3D9\uC548 \uD074\uB85C\uB2C8\uB518\uC758 \uC6A9\uB7C9\uC744 \uC810\uCC28\uC801\uC73C\uB85C \uC904\uC5EC\uC57C \uD55C\uB2E4. \uB610\uD55C \uD074\uB85C\uB2C8\uB518\uC5D0\uC11C \uC774 \uC57D\uC73C\uB85C \uBCC0\uACBD\uD558\uB294 \uACBD\uC6B0 \uD074\uB85C\uB2C8\uB518\uC744 \uC911\uB2E8\uD558\uACE0 \uBA70\uCE60 \uD6C4\uBD80\uD130 \uC774 \uC57D\uC744 \uD22C\uC5EC\uD560 \uAC83\uC774 \uAD8C\uC7A5\uB41C\uB2E4.\r\n<P><\/P>5)\uAE09\uACA9\uD558\uAC8C \uD22C\uC5EC\uB97C \uC911\uB2E8\uD558\uC5EC\uC11C\uB294 \uC548\uB418\uBA70(\uD2B9\uD788 \uB9CC\uC131\uC548\uC815\uD611\uC2EC\uC99D, \uD5C8\uD608\uC2EC\uC9C8\uD658\uC774 \uC788\uB294 \uD658\uC790\uB294 \uD611\uC2EC\uC99D \uBC1C\uC791\uC758 \uBE48\uB3C4\uC640 \uD1B5\uC99D\uC774 \uC2EC\uD574\uC9C8 \uC218 \uC788\uC73C\uBA70, \uB4DC\uBB3C\uAC8C \uC2EC\uADFC\uACBD\uC0C9 \uB610\uB294 \uC77C\uC2DC\uC801\uC778 \uD608\uC555\uC0C1\uC2B9\uC774 \uC77C\uC5B4\uB0A0 \uC218 \uC788\uB2E4.), 2\uC8FC\uAC04 \uC810\uCC28\uC801\uC73C\uB85C \uC911\uB2E8\uD55C\uB2E4. \uD611\uC2EC\uC99D \uC545\uD654\uB97C \uB9C9\uAE30\uC704\uD574 \uD544\uC694\uD560 \uB54C \uD56D\uD611\uC2EC\uC99D\uC57D\uC744 \uD22C\uC5EC\uD55C\uB2E4.\r\n<P><\/P>6)\uC2EC\uBC15\uC218\uAC00 \uBD84\uB2F9 55\uD68C \uC774\uD558\uB85C \uB5A8\uC5B4\uC9C0\uB294 \uACBD\uC6B0 \uC6A9\uB7C9\uC744 \uC810\uCC28 \uC904\uC774\uACE0 \uBD84\uB2F9 50\uD68C \uC774\uD558\uB85C \uB5A8\uC5B4\uC9C0\uB294 \uACBD\uC6B0 \uC774 \uC57D \uCE58\uB8CC\uAC00 \uC911\uB2E8\uB418\uC5B4\uC57C \uD558\uBA70, 1\uB3C4 \uBC29\uC2E4\uCC28\uB2E8\uC774 \uC788\uB294 \uACBD\uC6B0 \uC8FC\uC758\uD558\uC5EC \uD22C\uC57D\uD55C\uB2E4.\r\n<P><\/P>7)\uB2E4\uB978 \uBCA0\uD0C0\uCC28\uB2E8\uC81C\uC640 \uB9C8\uCC2C\uAC00\uC9C0\uB85C \uAC11\uC0C1\uC0D8\uAE30\uB2A5\uD56D\uC9C4\uC99D \uC99D\uC0C1\uC744 \uC740\uD3D0\uD560 \uC218 \uC788\uB2E4. \uB610\uD55C \uAC11\uC0C1\uC0D8\uAE30\uB2A5\uD56D\uC9C4\uC99D \uD658\uC790\uB294 \uAC11\uC790\uAE30 \uD22C\uC5EC\uB97C \uC911\uB2E8\uD558\uBA74 \uC99D\uC0C1\uC744 \uC545\uD654(\uC608, \uAC11\uC0C1\uC0D8\uD56D\uC9C4\uC99D\uC0C1 \uC545\uD654, \uAC11\uC0C1\uC0D8\uB3C5\uC131\uBC1C\uC791 \uB4F1) \uC2DC\uD0AC \uC218 \uC788\uC73C\uBBC0\uB85C \uC911\uB2E8\uC774 \uD544\uC694\uD55C \uACBD\uC6B0 \uD658\uC790\uC758 \uC0C1\uD0DC\uB97C \uCDA9\uBD84\uD788 \uAD00\uCC30\uD558\uBA70 1~2\uC8FC\uAC04\uC5D0 \uAC78\uCCD0 \uB2E8\uACC4\uC801\uC73C\uB85C \uAC10\uB7C9\uD574\uC57C \uD55C\uB2E4. \uB610\uD55C \uAC10\uB7C9\uC2DC \uD658\uC790\uC5D0\uAC8C \uC2E0\uCCB4\uC801 \uD65C\uB3D9\uC744 \uC904\uC774\uB3C4\uB85D \uD55C\uB2E4.\r\n<P><\/P>8)\uCF58\uD0DD\uD2B8\uB80C\uC988\uB97C \uC0AC\uC6A9\uD558\uB294 \uC790\uB294 \uB208\uBB3C\uC774 \uAC10\uC18C\uB420 \uC218 \uC788\uB2E4.\r\n<P><\/P>9)\uD55C\uAD6D\uC778\uC744 \uB300\uC0C1\uC73C\uB85C \uD55C \uC5F0\uAD6C\uACB0\uACFC CYP2D6 extensive metabolizer \uBCF4\uB2E4 poor metabolizer \uD658\uC790\uC5D0\uC11C \uCE74\uB974\uBCA0\uB51C\uB864\uC758 \uCCB4\uB0B4 \uB3D9\uD0DC\uAC00 \uB192\uAC8C \uAD00\uCC30\uB418\uC5C8\uB294 \uBC14, CYP2D6 poor metabolizer \uD658\uC790\uC5D0\uC11C \uC8FC\uC758\uD558\uC5EC \uC0AC\uC6A9\uD55C\uB2E4.\r\n<P><\/P>10)\uC218\uC220 \uC804 48\uC2DC\uAC04\uC740 \uD22C\uC5EC\uD558\uC9C0 \uC54A\uB294 \uAC83\uC774 \uBC14\uB78C\uC9C1\uD558\uB2E4. \uC2EC\uADFC\uAE30\uB2A5\uC744 \uAC10\uC18C\uC2DC\uD0A4\uB294 \uB9C8\uCDE8\uC81C \uD22C\uC5EC\uC2DC \uB9E4\uC6B0 \uC2E0\uC911\uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>11)\uC774 \uC57D\uC758 \uBCF5\uC6A9\uB7C9 \uC801\uC815 \uB2E8\uACC4 \uB3D9\uC548 \uC2EC\uADFC \uC218\uCD95\uB825 \uAC10\uC18C\uB85C \uC2EC\uBD80\uC804\uC99D\uC758 \uC545\uD654\uB97C \uCD08\uB798\uD560 \uC218 \uC788\uB2E4.\r\n<P><\/P>12)\uC774 \uC57D\uC758 \uCCAB \uBCF5\uC6A9\uD6C4, \uCE58\uB8CC \uCCAB \uC8FC, \uADF8\uB9AC\uACE0 \uC6A9\uB7C9 \uC99D\uAC00\uC2DC \uD608\uC555\uACFC \uC2EC\uC804\uB3C4\uB97C \uC8FC\uAE30\uC801\uC73C\uB85C \uAC80\uC0AC\uD560 \uAC83\uC774 \uAD8C\uC7A5\uB418\uBA70 \uC720\uD6A8\uC6A9\uB7C9\uC5D0 \uB3C4\uB2EC\uD558\uBA74 \uC2E0\uC7A5\uAE30\uB2A5\uC758 \uC8FC\uAE30\uC801\uC778 \uAC80\uC0AC\uB3C4 \uC2E4\uC2DC\uD560 \uAC83\uC744 \uAD8C\uC7A5\uD55C\uB2E4. \uC2E4\uC2E0 \uD639\uC740 \uACFC\uB3C4\uD55C \uD608\uC555\uAC15\uD558\uB97C \uC904\uC774\uAE30 \uC704\uD574 \uC774 \uC57D\uC740 \uB0AE\uC740 \uC6A9\uB7C9\uC5D0\uC11C \uC2DC\uC791\uD574\uC11C \uC810\uCC28\uC801\uC73C\uB85C \uC99D\uB7C9\uD558\uBA70, \uC74C\uC2DD\uACFC \uD568\uAED8 \uBCF5\uC6A9\uD560 \uAC83\uC744 \uAD8C\uC7A5\uB41C\uB2E4. \uCE58\uB8CC \uC2DC\uC791\uC2DC \uD658\uC790\uB294 \uC6B4\uC804 \uD639\uC740 \uC704\uD5D8\uD55C \uC791\uC5C5\uC744 \uC218\uD589\uD558\uC9C0 \uC54A\uC544\uC57C \uD55C\uB2E4.\r\n<P><\/P>13)\uC774 \uC57D\uC740 \uB3C4\uD551\uAC80\uC0AC \uC2DC \uC2E4\uC2DC\uB418\uB294 \uD14C\uC2A4\uD2B8\uB4E4\uC5D0\uC11C \uC591\uC131 \uBC18\uC751\uC744 \uCD08\uB798\uD560 \uC218 \uC788\uB294 \uC720\uD6A8\uC131\uBD84\uC744 \uD3EC\uD568\uD558\uACE0 \uC788\uB2E4.\r\n<P><\/P>14)\uC2EC\uBD80\uC804\uC758 \uACBD\uC6B0, \uC774 \uC57D\uC758 \uCE58\uB8CC\uAC00 2\uC8FC \uC774\uC0C1 \uC911\uB2E8\uB418\uBA74 \uCE58\uB8CC \uC6A9\uB7C9\uC740 \uB2E4\uC2DC 1\uC77C 2\uD68C 3.125mg (\uC11C\uBC29\uC131 \uC81C\uC81C\uC758 \uACBD\uC6B0 1\uC77C 1\uD68C 8mg)\uC774 \uAD8C\uC7A5\uB418\uBA70 \uC704\uC758 \uC6A9\uB7C9 \uC99D\uB7C9\uC5D0 \uB9DE\uCDB0 \uC6A9\uB7C9\uC744 \uC99D\uB7C9\uC2DC\uD0AC \uAC83\uC774 \uAD8C\uC7A5\uB41C\uB2E4.\r\n<P><\/P>15)\uC774 \uC57D\uC740 \uB2F9\uB1E8\uBCD1\uD658\uC790\uC5D0\uAC8C \uD22C\uC5EC\uC2DC \uAE09\uACA9\uD55C \uD608\uB2F9\uAC15\uD558\uAC00 \uC740\uD3D0\uB418\uAC70\uB098 \uC801\uAC8C \uB098\uD0C0\uB0A0 \uC218 \uC788\uACE0, \uD608\uB2F9\uC870\uC808\uC774 \uC5B4\uB824\uC6CC\uC9C8 \uC218 \uC788\uC73C\uBBC0\uB85C \uBCF5\uC6A9\uC744 \uC2DC\uC791\uD560 \uB54C, \uD639\uC740 \uD608\uB2F9\uAC15\uD558\uC694\uBC95\uC744 \uC870\uC808\uD560 \uB54C \uADDC\uCE59\uC801\uC73C\uB85C \uD608\uB2F9\uC744 \uBAA8\uB2C8\uD130\uB9C1 \uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>16)\uC774 \uC57D\uC744 \uD22C\uC5EC\uC2DC \uAC00\uC5ED\uC801\uC778 \uC2E0\uAE30\uB2A5 \uC7A5\uC560\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uC73C\uBBC0\uB85C \uD22C\uC5EC\uC2DC\uC791, \uC99D\uB7C9\uD560 \uB54C \uC2E0\uAE30\uB2A5\uC744 \uBAA8\uB2C8\uD130\uB9C1 \uD574\uC57C\uD558\uBA70, \uC2E0\uAE30\uB2A5\uC774 \uC545\uD654\uB418\uB294 \uACBD\uC6B0 \uC774 \uC57D\uC758 \uC6A9\uB7C9\uC744 \uC904\uC774\uAC70\uB098 \uBCF5\uC6A9\uC744 \uC911\uC9C0\uD55C\uB2E4.\r\n<P><\/P>17)\uC6B8\uD608\uC2EC\uBD80\uC804 \uD658\uC790\uC5D0\uAC8C \uC774 \uC57D\uC744 \uC99D\uB7C9\uD560 \uB54C \uC2EC\uBD80\uC804\uC774 \uC545\uD654\uB418\uAC70\uB098 \uCCB4\uC561 \uC800\uB958\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4. \uC774\uB7EC\uD55C \uC99D\uC0C1\uC774 \uB098\uD0C0\uB098\uBA74 \uC774\uB1E8\uC81C \uC6A9\uB7C9\uC744 \uC870\uC808\uD574\uC57C \uD558\uACE0 \uC784\uC0C1\uC801\uC73C\uB85C \uC548\uC815\uB420 \uB54C\uAE4C\uC9C0 \uC774 \uC57D\uC744 \uC99D\uB7C9\uD574\uC11C\uB294 \uC548 \uB41C\uB2E4. \uB54C\uB54C\uB85C \uC774 \uC57D\uC744 \uAC10\uB7C9\uD558\uAC70\uB098 \uC911\uB2E8\uD560 \uD544\uC694\uAC00 \uC788\uB2E4.\r\n<P><\/P>18)\uD658\uC790\uC5D0 \uB530\uB77C \uC5B4\uC9C0\uB7FC, \uC878\uC74C \uB4F1\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uC73C\uBA70 \uAC01\uC131\uC0C1\uD0DC\uC5D0 \uC601\uD5A5\uC744 \uBBF8\uCE58\uBBC0\uB85C \uC6B4\uC804, \uAE30\uACC4\uC870\uC791 \uB4F1\uC5D0 \uC8FC\uC758\uD558\uBA70, \uD2B9\uD788 \uC774 \uC57D\uC758 \uD22C\uC5EC\uC2DC\uC791, \uC6A9\uB7C9\uBCC0\uD654, \uCE58\uB8CC\uBCC0\uD654, \uC54C\uCF54\uC62C\uBCF5\uC6A9 \uC2DC \uC8FC\uC758\uD55C\uB2E4.\r\n<P><\/P>19)\uBCF8\uC81C \uD22C\uC5EC \uC911\uC5D0 \uB9E4\uC6B0 \uB4DC\uBB3C\uAC8C \uB3C5\uC131\uD45C\uD53C\uAD34\uC0AC\uC6A9\uD574 (Toxic Epidermal Necrolysis) \uBC0F \uC2A4\uD2F0\uBE10\uC2A4-\uC874\uC2A8\uC99D\uD6C4\uAD70 (Stevens-Johnson Syndrome)\uACFC \uAC19\uC740 \uC911\uC99D \uD53C\uBD80 \uC774\uC0C1\uBC18\uC751\uC774 \uBCF4\uACE0\uB418\uC5C8\uC73C\uBA70, \uBCF8\uC81C\uC5D0 \uAE30\uC778\uD560 \uAC00\uB2A5\uC131\uC774 \uC788\uB294 \uC911\uC99D \uD53C\uBD80 \uC774\uC0C1\uBC18\uC751\uC744 \uACBD\uD5D8\uD55C \uD658\uC790\uC5D0\uC11C \uC601\uAD6C\uC801\uC73C\uB85C \uBCF8\uC81C \uD22C\uC57D\uC744 \uC911\uB2E8\uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>5. \uC0C1\uD638\uC791\uC6A9\r\n<P><\/P>1)\uC774 \uC57D\uC740 P-\uB2F9\uB2E8\uBC31\uC9C8\uC758 \uAE30\uC9C8\uC774\uBA74\uC11C \uC5B5\uC81C\uC81C\uC774\uAE30 \uB54C\uBB38\uC5D0 P-\uB2F9\uB2E8\uBC31\uC9C8\uC744 \uD1B5\uD574 \uC6B4\uBC18\uB418\uB294 \uC57D\uBB3C\uB4E4\uC758 \uC0DD\uCCB4\uC774\uC6A9\uB960\uC740 \uC774 \uC57D\uC744 \uBCD1\uC6A9\uD22C\uC5EC\uD558\uAC8C \uB418\uBA74 \uC99D\uAC00\uD560 \uC218 \uC788\uB2E4. \uADF8\uB9AC\uACE0 \uC774 \uC57D\uC758 \uC0DD\uCCB4\uC774\uC6A9\uB960\uC740 P-\uB2F9\uB2E8\uBC31\uC9C8\uC758 \uC720\uB3C4\uC81C \uB610\uB294 \uC5B5\uC81C\uC81C\uC5D0 \uB530\uB77C \uBCC0\uD560 \uC218 \uC788\uB2E4.\r\n<P><\/P>2)CYP2D6\uC640 CYP2C9\uC758 \uC5B5\uC81C\uC81C\uC640 \uC720\uB3C4\uC81C\uB294 \uC785\uCCB4\uC120\uD0DD\uC801\uC73C\uB85C \uC774 \uC57D\uC758 \uB300\uC0AC\uB97C \uBCC0\uD654\uC2DC\uCF1C R-\uACFC S-\uC774\uC131\uC9C8\uCCB4\uC758 \uD608\uC7A5 \uB18D\uB3C4\uB97C \uC99D\uAC00\uC2DC\uD0A4\uAC70\uB098 \uAC10\uC18C\uC2DC\uD0AC \uC218 \uC788\uB2E4.\r\n<P><\/P>3)\uB2E4\uB978 \uD608\uC555\uAC15\uD558\uC791\uC6A9\uC774 \uC788\uB294 \uC57D\uBB3C\uC774\uB098 \uC774\uC0C1\uBC18\uC751 \uC911 \uD608\uC555\uAC15\uD558\uAC00 \uC788\uB294 \uC57D\uBB3C(\uC608, \uBC14\uB974\uBE44\uD22C\uB974\uC0B0\uC5FC, \uD398\uB178\uD2F0\uC544\uC9C4 \uB4F1\uC758 \uC9C4\uC815\uC81C, \uD56D\uC6B0\uC6B8\uC81C, \uD608\uAD00\uD655\uC7A5\uC81C, \uC54C\uCF54\uC62C \uB4F1)\uC758 \uC791\uC6A9\uC774 \uC99D\uAC00\uB420 \uC218 \uC788\uC73C\uBA70, \uB808\uC138\uB974\uD540, \uAD6C\uC544\uB124\uD2F0\uB518, \uBA54\uD2F8\uB3C4\uD30C, \uD074\uB85C\uB2C8\uB518, \uAD6C\uC548\uD30C\uC2E0, MAO\uC5B5\uC81C\uC81C \uB4F1\uACFC \uBCD1\uC6A9\uC2DC \uC2EC\uBC15\uC218\uAC00 \uB354\uC6B1 \uAC10\uC18C, \uC911\uC99D\uC758 \uC11C\uB9E5\uC774 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>4)\uB51C\uD2F0\uC544\uC82C\uACFC \uBCD1\uC6A9\uD558\uC5EC \uACBD\uAD6C\uD22C\uC5EC\uC2DC \uC2EC\uC7A5\uC758 \uC804\uB3C4\uC7A5\uC560(\uB4DC\uBB3C\uAC8C \uD608\uC5ED\uD559\uC801 \uC190\uC0C1\uACFC \uD568\uAED8)\uAC00 \uBCF4\uACE0\uB418\uC5C8\uB2E4. \uBCA0\uB77C\uD30C\uBC00, \uB51C\uD2F0\uC544\uC82C \uB4F1 \uCE7C\uC298\uCC44\uB110\uCC28\uB2E8\uC81C, \uC544\uBBF8\uC624\uB2E4\uB860 \uB4F1 \uBD80\uC815\uB9E5\uCE58\uB8CC\uC81C\uC640 \uBCD1\uC6A9\uD22C\uC5EC\uC2DC \uC2EC\uBC15\uC774 \uB290\uB824\uC9C8 \uC218 \uC788\uACE0, \uACFC\uB3C4\uD55C \uC2EC\uAE30\uB2A5 \uC5B5\uC81C\uAC00 \uB098\uD0C0\uB0A0 \uC218 \uC788\uC73C\uBA70, \uBC29\uC2E4\uC804\uB3C4\uC7A5\uC560\uC758 \uC704\uD5D8\uC744 \uB192\uC77C \uC218 \uC788\uC73C\uBBC0\uB85C \uC2EC\uC804\uB3C4\uC640 \uD608\uC555\uC744 \uC8FC\uC758\uAE4A\uAC8C \uBAA8\uB2C8\uD130\uB9C1\uD574\uC57C \uD558\uBA70, \uBCD1\uC6A9\uD558\uC5EC \uC815\uB9E5\uC8FC\uC0AC\uD558\uC5EC\uC11C\uB294 \uC548\uB41C\uB2E4.\r\n<P><\/P>5)\uACE0\uD608\uC555\uD658\uC790\uC5D0\uAC8C \uB514\uACE1\uC2E0\uACFC \uBCD1\uC6A9\uD22C\uC5EC\uC2DC \uB514\uACE1\uC2E0\uC758 \uD608\uC911\uB18D\uB3C4\uAC00 \uC57D 15 %(\uCD5C\uB300 60 %) \uC0C1\uC2B9\uB418\uC5C8\uB2E4\uB294 \uBCF4\uACE0\uAC00 \uC788\uC73C\uBBC0\uB85C, \uC774 \uC57D\uC758 \uBCF5\uC6A9\uC744 \uC2DC\uC791, \uC911\uB2E8\uD560 \uB54C \uBC0F \uC6A9\uB7C9\uC744 \uC870\uC808\uD560 \uB54C \uB514\uACE1\uC2E0 \uB18D\uB3C4\uB97C \uBAA8\uB2C8\uD130\uB9C1\uD574\uC57C \uD55C\uB2E4. \uB610\uD55C \uAC15\uC2EC\uBC30\uB2F9\uCCB4\uC640 \uBCD1\uC6A9\uC2DC \uC2EC\uBC15\uC218\uAC00 \uD604\uC800\uD788 \uC801\uC5B4\uC9C0\uACE0 \uBC29\uC2E4\uC804\uB3C4\uAC00 \uC9C0\uC5F0\uB420 \uC218 \uC788\uB2E4.\r\n<P><\/P>6)\uC2DC\uD074\uB85C\uC625\uC2DC\uAC8C\uB098\uC81C \uC5B5\uC81C\uC81C(\uC608, \uC544\uC138\uD2F8\uC0B4\uB9AC\uC2E4\uC0B0, \uCF54\uB974\uD2F0\uCF54\uC2A4\uD14C\uB85C\uC774\uB4DC \uB4F1)\uB294 \uC774 \uC57D\uC758 \uD608\uC555\uAC15\uD558\uD6A8\uACFC\uB97C \uB0AE\uCD9C \uC218 \uC788\uB2E4.\r\n<P><\/P>7)\uC778\uC290\uB9B0 \uB610\uB294 \uACBD\uAD6C\uD608\uB2F9\uAC15\uD558\uC81C\uC758 \uD6A8\uACFC\uB97C \uC99D\uAC15\uC2DC\uD0AC \uC218 \uC788\uC73C\uBA70, \uC800\uD608\uB2F9\uC99D\uC0C1(\uD2B9\uD788 \uC2EC\uBC15\uC218\uC758 \uC99D\uAC00)\uC774 \uC740\uD3D0\uB420 \uC218 \uC788\uB2E4. \uC778\uC290\uB9B0 \uB610\uB294 \uACBD\uAD6C\uD608\uB2F9\uAC15\uD558\uC81C\uB97C \uBCF5\uC6A9\uD558\uB294 \uD658\uC790\uC758 \uACBD\uC6B0 \uC815\uAE30\uC801\uC73C\uB85C \uD608\uB2F9\uC744 \uBAA8\uB2C8\uD130\uB9C1 \uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>8)Mixed function oxidase\uB97C \uC720\uB3C4\uC2DC\uD0A4\uB294 \uBB3C\uC9C8(\uC608, \uB9AC\uD31C\uD53C\uC2E0 \uB4F1)\uC740 \uC774 \uC57D\uC758 \uD608\uC7A5\uB18D\uB3C4\uB97C \uAC10\uC18C\uC2DC\uD0A4\uBA70, \uC0C1\uAE30 \uD6A8\uC18C\uC758 \uC5B5\uC81C\uC81C(\uC608, \uC2DC\uBA54\uD2F0\uB518 \uB4F1)\uB294 \uAC04\uB300\uC0AC\uB97C \uB0AE\uCD94\uC5B4 \uC774 \uC57D\uC758 \uD608\uC7A5\uB18D\uB3C4\uB97C \uC99D\uAC00\uC2DC\uD0AC \uC218 \uC788\uB2E4.\r\n<P><\/P>9)\uC774 \uC57D\uC744 \uB9C8\uCDE8\uC81C, \uB9C8\uC57D\uACFC \uD568\uAED8 \uBCF5\uC6A9 \uC2DC \uAC01\uAC01\uC758 \uC218\uCD95\uB825 \uAC10\uC18C \uD6A8\uACFC\uC640 \uD608\uC555\uAC15\uD558 \uD6A8\uACFC\uB97C \uC0C1\uC2B9\uC2DC\uD0AC \uC218 \uC788\uC73C\uBBC0\uB85C \uB9C8\uCDE8\uD558\uB294 \uB3D9\uC548 \uD65C\uB825\uC9D5\uD6C4\uB97C \uC8FC\uC758\uAE4A\uAC8C \uBAA8\uB2C8\uD130\uB9C1\uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>10)\uACBD\uAD6C\uC6A9 \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0 \uC81C\uC81C\uB97C \uBCF5\uC6A9\uD558\uB294 \uC2E0\uC7A5\uC774\uC2DD\uD658\uC790\uC640 \uC2EC\uC7A5\uC774\uC2DD\uD658\uC790\uB97C \uB300\uC0C1\uC73C\uB85C \uC2E4\uC2DC\uD55C \uB450 \uAC1C\uC758 \uC784\uC0C1\uC2DC\uD5D8\uC5D0\uC11C \uC774 \uC57D\uC744 \uBCF5\uC6A9\uD558\uAE30 \uC2DC\uC791\uD55C \uD6C4 \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0\uC758 \uD608\uC7A5\uB18D\uB3C4\uAC00 \uC0C1\uC2B9\uD558\uC600\uB2E4. \uC774 \uC57D\uC740 \uC7A5\uC5D0\uC11C P-\uB2F9\uB2E8\uBC31\uC9C8 \uD65C\uC131\uC744 \uC800\uD574\uD558\uC5EC \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0\uC758 \uACBD\uC6B0 \uD761\uC218\uB97C \uC99D\uAC00\uC2DC\uD0A4\uB294 \uAC83\uC73C\uB85C \uB098\uD0C0\uB0AC\uB2E4. \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0\uC758 \uCE58\uB8CC\uD559\uC801 \uB18D\uB3C4\uB97C \uC720\uC9C0\uD558\uAE30 \uC704\uD574 \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0\uC758 \uC6A9\uB7C9\uC744 \uD3C9\uADE0 10 \uFF5E 20 % \uAC10\uB7C9\uD558\uB294 \uAC83\uC774 \uD544\uC694\uD558\uB2E4. \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0 \uB18D\uB3C4\uC758 \uAC1C\uC778\uAC04 \uBCC0\uC774\uAC00 \uD06C\uAE30 \uB54C\uBB38\uC5D0 \uC774 \uC57D\uC744 \uD22C\uC57D\uD558\uAE30 \uC2DC\uC791\uD55C \uD6C4 \uC2DC\uD074\uB85C\uC2A4\uD3EC\uB9B0\uC758 \uB18D\uB3C4\uB97C \uBAA8\uB2C8\uD130\uB9C1 \uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>11)12\uBA85\uC758 \uAC74\uAC15\uD55C \uD53C\uD5D8\uC790\uB97C \uB300\uC0C1\uC73C\uB85C \uD55C \uC784\uC0C1\uC2DC\uD5D8\uC5D0\uC11C \uB9AC\uD31C\uD53C\uC2E0\uC758 \uD22C\uC5EC\uB294 \uC8FC\uB85C P-\uB2F9\uB2E8\uBC31\uC9C8\uC758 \uC720\uB3C4\uB97C \uD1B5\uD574 \uC774 \uC57D\uC758 \uD608\uC7A5\uB18D\uB3C4\uB97C \uAC10\uC18C\uC2DC\uCF1C \uC774 \uC57D\uC758 \uC7A5 \uD761\uC218\uB97C \uAC10\uC18C\uC2DC\uD0A4\uACE0 \uD56D\uACE0\uD608\uC555 \uD6A8\uACFC\uB97C \uAC10\uC18C\uC2DC\uCF30\uB2E4.\r\n<P><\/P>12)CYP2C9\uC758 \uC5B5\uC81C\uC81C\uC778 \uC544\uBBF8\uC624\uB2E4\uB860\uC740 \uCE74\uB974\uBCA0\uB51C\uB864\uC758 S-\uC774\uC131\uC9C8\uCCB4\uC758 \uD608\uC7A5\uB18D\uB3C4\uB97C 2\uBC30 \uC774\uC0C1 \uC99D\uAC00\uC2DC\uCF30\uB2E4. \uB530\uB77C\uC11C \uC544\uBBF8\uC624\uB2E4\uB860\uACFC \uAC19\uC740 CYP2C9\uC758 \uC5B5\uC81C\uC81C\uB97C \uBCD1\uC6A9\uD558\uB294 \uACBD\uC6B0 \uBCA0\uD0C0\uCC28\uB2E8\uD6A8\uACFC\uAC00 \uC99D\uAC00\uB420 \uC704\uD5D8\uC774 \uC788\uC73C\uBBC0\uB85C \uC11C\uB9E5 \uB610\uB294 \uC2EC\uC815\uC9C0 \uB4F1\uC758 \uC9D5\uD6C4\uB97C \uAD00\uCC30\uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>13)\uBCA0\uD0C0\uCC28\uB2E8\uC81C\uC640 \uCE74\uD14C\uCF5C\uC544\uBBFC\uC744 \uC18C\uC2E4\uC2DC\uD0A4\uB294 \uC57D\uBB3C(\uC608, \uB808\uC138\uB974\uD540, MAO\uC5B5\uC81C\uC81C)\uC744 \uBCF5\uC6A9\uD558\uB294 \uD658\uC790\uB294 \uC800\uD608\uC555 \uADF8\uB9AC\uACE0\/\uB610\uB294 \uC911\uC99D\uC758 \uC11C\uB9E5 \uC99D\uC0C1\uC744 \uC2E0\uC911\uD788 \uAD00\uCC30\uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>14)\uBE44\uC2A4\uD14C\uB85C\uC774\uB4DC\uC18C\uC5FC\uC9C4\uD1B5\uC81C(NSAID)\uC640 \uBCA0\uD0C0\uCC28\uB2E8\uC81C\uB97C \uBCD1\uC6A9\uD22C\uC5EC\uC2DC \uD608\uC555\uC774 \uC99D\uAC00\uD558\uACE0 \uD608\uC555\uC774 \uC798 \uC870\uC808\uB418\uC9C0 \uC54A\uC744 \uC218 \uC788\uB2E4.\r\n<P><\/P>15)\uC2EC\uC7A5 \uBE44\uC120\uD0DD\uC801\uC778 \uBCA0\uD0C0\uCC28\uB2E8\uC81C\uB294 \uBCA0\uD0C0\uD6A8\uB2A5 \uAE30\uAD00\uC9C0\uD655\uC7A5\uC81C\uC758 \uAE30\uAD00\uC9C0\uD655\uC7A5\uD6A8\uACFC\uB97C \uBC29\uD574\uD558\uBBC0\uB85C \uAE30\uAD00\uC9C0\uD655\uC7A5\uC81C\uB97C \uBCF5\uC6A9\uD558\uB294 \uCC9C\uC2DD\uD658\uC790\uC758 \uACBD\uC6B0 \uC2E0\uC911\uD788 \uBAA8\uB2C8\uD130\uB9C1 \uD574\uC57C \uD55C\uB2E4.\r\n<P><\/P>16)\uD56D\uCF5C\uB9B0\uC5D0\uC2A4\uD130\uB77C\uC81C\uC640 \uBCD1\uC6A9\uC2DC \uC9C0\uB098\uCE5C \uC11C\uB9E5\uC774 \uC704\uD5D8\uC774 \uC788\uB2E4.\r\n<P><\/P>17)\uBC14\uD074\uB85C\uD39C\uACFC \uBCD1\uC6A9\uC2DC \uD608\uC555\uAC15\uD558\uD6A8\uACFC\uAC00 \uCEE4\uC9C0\uACE0 \uD2B9\uD788 \uAE30\uB9BD\uC800\uD608\uC555\uC758 \uC704\uD5D8\uC774 \uC788\uB2E4.\r\n<P><\/P>18)\uC0BC\uD658\uACC4 \uD56D\uC6B0\uC6B8\uC81C \uBC0F \uC2E0\uACBD\uC774\uC644\uC81C\uC640 \uBCD1\uC6A9\uC2DC \uD608\uAD00\uD655\uC7A5\uC791\uC6A9 \uBC0F \uAE30\uB9BD\uC800\uD608\uC555\uC758 \uC704\uD5D8 \uC99D\uAC00\uC758 \uC704\uD5D8\uC774 \uC788\uB2E4.\r\n<P><\/P>6. \uC784\uBD80 \uBC0F \uC218\uC720\uBD80\uC5D0 \uB300\uD55C \uD22C\uC5EC\r\n<P><\/P>1)\uC784\uBD80 \uBC0F \uC784\uC2E0\uD558\uACE0 \uC788\uC744 \uAC00\uB2A5\uC131\uC774 \uC788\uB294 \uC5EC\uC131\uC5D0\uAC8C\uB294 \uC548\uC804\uC131\uC774 \uD655\uB9BD\uB418\uC5B4 \uC788\uC9C0 \uC54A\uAE30 \uB54C\uBB38\uC5D0 \uD22C\uC5EC\uD558\uC9C0 \uC54A\uB294\uB2E4. \uBCA0\uD0C0\uCC28\uB2E8\uC81C\uB294 \uD0DC\uBC18\uAD00\uB958\uB97C \uB9C9\uC544\uC11C \uD0DC\uC544\uC758 \uC790\uAD81 \uB0B4 \uC0AC\uB9DD \uD639\uC740 \uAE30\uD615\uC544 \uCD9C\uC0B0, \uC870\uC0B0 \uCD9C\uC0B0\uC774 \uC77C\uC5B4\uB0A0 \uC218 \uC788\uB2E4. \uB610\uD55C \uC2E0\uC0DD\uC544\uC5D0\uAC8C\uB3C4 \uC800\uD608\uB2F9\uC99D, \uC11C\uB9E5, \uD638\uD761\uC800\uD558, \uADF8\uB9AC\uACE0 \uACE0\uC5F4 \uB4F1\uC744 \uC77C\uC73C\uD0AC \uC218 \uC788\uB2E4. \uB610\uD55C \uAE09\uC131\uD3D0\uBD80\uC885 \uD639\uC740 \uC785\uC6D0\uC744 \uD544\uC694\uB85C \uD558\uB294 \uC2EC\uBD80\uC804\uAE4C\uC9C0 \uB098\uD0C0\uB0A0 \uC218 \uC788\uB2E4.\r\n<P><\/P>2)\uC774 \uC57D\uC758 \uB300\uC0AC\uBB3C\uC740 \uBAA8\uC720\uB85C \uC774\uD589\uB418\uBBC0\uB85C, \uC774 \uC57D \uBCF5\uC6A9 \uC2DC \uC218\uC720\uD558\uC9C0 \uC54A\uB294\uB2E4. \uC218\uC720\uD558\uB294 \uC5EC\uC131\uC5D0\uAC8C\uB294 \uC774 \uC57D\uC744 \uD22C\uC5EC\uD558\uC9C0 \uC54A\uB294\uB2E4.\r\n<P><\/P>7. \uC18C\uC544\uC5D0 \uB300\uD55C \uD22C\uC5EC\r\n<P><\/P>18\uC138 \uBBF8\uB9CC \uC18C\uC544 \uBC0F \uCCAD\uC18C\uB144\uC5D0 \uB300\uD55C \uC548\uC804\uC131 \uBC0F \uC720\uD6A8\uC131\uC740 \uD655\uB9BD\uB418\uC5B4 \uC788\uC9C0 \uC54A\uB2E4. \uC911\uC99D \uC2EC\uBD80\uC804\uC774 \uC788\uB294 \uC720\uC544 \uBC0F \uC18C\uC544\uC5D0\uC11C \uC774 \uC57D\uC758 \uD22C\uC5EC\uC5D0 \uC758\uD574 \uC2EC\uD55C \uC800\uD608\uB2F9 \uC99D\uC0C1\uC774 \uB098\uD0C0\uB098 \uC0AC\uB9DD\uC5D0 \uC774\uB978 \uC608\uB3C4 \uBCF4\uACE0\uB41C \uBC14 \uC788\uB2E4.\r\n<P><\/P>8. \uACE0\uB839\uC790\uC5D0 \uB300\uD55C \uD22C\uC5EC\r\n<P><\/P>\uC774 \uC57D\uC740 \uC8FC\uB85C \uAC04\uC5D0\uC11C \uB300\uC0AC\uB418\uB294 \uC57D\uBB3C\uC774\uBA70, \uC911\uC99D \uAC04\uC7A5\uC560 \uD658\uC790\uC5D0\uC11C \uD608\uC911 \uB18D\uB3C4 \uC0C1\uC2B9\uC774 \uBCF4\uACE0\uB41C \uBC14 \uC788\uB2E4. \uC77C\uBC18\uC801\uC73C\uB85C \uACE0\uB839\uC790\uB294 \uAC04\uAE30\uB2A5\uC774 \uC800\uD558\uB418\uC5B4 \uC788\uB294 \uACBD\uC6B0\uAC00 \uB9CE\uAE30 \uB54C\uBB38\uC5D0 \uD608\uC911 \uB18D\uB3C4\uAC00 \uC0C1\uC2B9\uD560 \uC6B0\uB824\uAC00 \uC788\uC73C\uBA70, \uACE0\uB839\uC790\uC5D0\uAC8C\uC11C \uACFC\uB3C4\uD55C \uD608\uC555\uAC15\uD558\uB294 \uB1CC\uACBD\uC0C9 \uB4F1\uC774 \uC77C\uC5B4\uB0A0 \uC6B0\uB824\uAC00 \uC788\uC5B4 \uBC14\uB78C\uC9C1\uD558\uC9C0 \uC54A\uB2E4. \uB530\uB77C\uC11C \uACE0\uB839\uC790\uC5D0\uAC8C \uD22C\uC5EC\uC2DC \uB0AE\uC740 \uC6A9\uB7C9\uC5D0\uC11C \uD22C\uC5EC\uB97C \uC2DC\uC791\uD558\uB294 \uB4F1 \uD658\uC790\uC758 \uC0C1\uD0DC\uB97C \uCDA9\uBD84\uD788 \uAD00\uCC30\uD558\uBA70 \uC2E0\uC911\uD788 \uD22C\uC5EC\uD560 \uAC83\uC774 \uAD8C\uC7A5\uB41C\uB2E4.\r\n<P><\/P>9. \uACFC\uB7C9\uD22C\uC5EC\uC2DC\uC758 \uCC98\uCE58\r\n<P><\/P>\uACFC\uB7C9\uD22C\uC5EC\uC2DC \uD608\uC555\uC758 \uB69C\uB837\uD55C \uAC15\uD558, \uC2EC\uBC15\uC774 \uB290\uB824\uC9D0, \uC2EC\uADFC\uC57D\uD654, \uC2EC\uC7A5\uC131 \uC1FC\uD06C, \uC2EC\uC7A5\uC815\uC9C0, \uD638\uD761\uACE4\uB780, \uAE30\uAD00\uC9C0\uACBD\uB828, \uAD6C\uD1A0, \uC758\uC2DD\uC7A5\uC560, \uC804\uC2E0\uBC1C\uC791 \uB4F1\uC774 \uC77C\uC5B4\uB0A0 \uC218 \uC788\uB2E4. \uC774\uB7EC\uD55C \uC99D\uC0C1\uC774 \uBC1C\uC0DD\uD558\uBA74 \uC989\uC2DC \uC758\uC0AC\uC5D0\uAC8C \uBCF4\uACE0\uD558\uC5EC \uC801\uC808\uD55C \uC870\uCE58\uB97C \uCDE8\uD55C\uB2E4. \uACFC\uB7C9 \uD22C\uC5EC\uC2DC \uD658\uC790\uB294 \uBC14\uB85C\uB204\uC6B4\uC790\uC138\uB97C \uCDE8\uD558\uB3C4\uB85D \uD558\uACE0 \uC704\uC138\uCC99, \uAD6C\uD1A0\uC720\uB3C4 \uB4F1\uC73C\uB85C \uC57D\uC744 \uC81C\uAC70\uD55C\uB2E4. \uC774 \uC57D\uC740 \uD608\uC561 \uD22C\uC11D\uC5D0 \uC758\uD574 \uC81C\uAC70\uB418\uAE30 \uC5B4\uB835\uB2E4.\r\n<P><\/P>\uC1FC\uD06C \uC99D\uC0C1\uACFC \uD568\uAED8\uC911\uC99D \uC911\uB3C5\uC758 \uACBD\uC6B0, \uC774 \uC57D\uC758 \uC81C\uAC70 \uBC18\uAC10\uAE30\uAC00 \uAF64 \uAE38\uAE30 \uB54C\uBB38\uC5D0, \uD574\uB3C5\uC81C\uC640 \uD568\uAED8 \uBCF4\uC870\uC801 \uCE58\uB8CC\uAC00 \uCDA9\uBD84\uD788 \uC624\uB7AB\uB3D9\uC548 \uC9C0\uC18D\uB418\uC5B4\uC57C \uD55C\uB2E4. \uD574\uB3C5\uC81C \uCE58\uB8CC \uAE30\uAC04\uC740 \uACFC\uC789 \uD22C\uC5EC\uC758 \uC704\uC911\uB3C4\uC5D0 \uB530\uB77C \uB2EC\uB77C\uC9C4\uB2E4. \uBCF4\uC870 \uCE58\uB8CC\uB294 \uD658\uC790\uC758 \uD68C\uBCF5\uB54C\uAE4C\uC9C0 \uC9C0\uC18D\uB418\uC5B4\uC57C \uD55C\uB2E4.\r\n<P><\/P>10. \uC801\uC6A9\uC0C1\uC758 \uC8FC\uC758\r\n<P><\/P>1)\uC774 \uC57D\uC740 \uC88C\uC2EC\uC2E4\uBC15\uCD9C\uB960 45% \uC774\uD558, \uD734\uC2DD\uC2DC \uC2EC\uBC15\uC218\uAC00 \uBD84\uB2F9 65\uD68C \uC774\uC0C1\uC774\uBA70 \uAE30\uBCF8\uC801\uC778 \uC2EC\uBD80\uC804 \uCE58\uB8CC\uAC00 \uCD5C\uC18C 4\uC8FC \uC774\uC804\uC5D0 \uC548\uC815\uB41C \uD658\uC790(NYHA Class\uB098 \uAE30\uBCF8 \uCE58\uB8CC\uC5D0 \uBCC0\uB3D9\uC774 \uC5C6\uC73C\uBA70 \uC99D\uC0C1\uC545\uD654\uB85C \uC785\uC6D0\uD558\uB294 \uACBD\uC6B0\uAC00 \uBC1C\uC0DD\uD558\uC9C0 \uC54A\uB294 \uACBD\uC6B0)\uC5D0\uAC8C \uD22C\uC5EC\uD55C\uB2E4.\r\n<P><\/P>2)\uC99D\uB7C9 \uC2DC\uB9C8\uB2E4 \uC758\uC0AC\uB294 \uBC18\uB4DC\uC2DC \uD658\uC790\uC758 \uC2EC\uBD80\uC804 \uC99D\uC0C1\uC758 \uC545\uD654, \uD608\uAD00\uD655\uC7A5\uC73C\uB85C \uC778\uD55C \uC774\uC0C1\uBC18\uC751(\uD608\uC555\uAC15\uD558, \uC5B4\uC9C0\uB7FC)\uC774 \uB098\uD0C0\uB098\uB294\uC9C0 \uD655\uC778\uD558\uBA70, \uC815\uAE30\uC801\uC778 \uAC80\uC9C4(\uC2EC\uAE30\uB2A5, \uCCB4\uC911, \uD608\uC555, \uC2EC\uBC15\uC218 \uB4F1)\uC744 \uC2E4\uC2DC\uD574\uC57C \uD55C\uB2E4. \uC77C\uC2DC\uC801\uC73C\uB85C \uC2EC\uBD80\uC804 \uC99D\uC0C1\uC774 \uC545\uD654\uB418\uAC70\uB098 \uCCB4\uC561\uC774 \uC800\uB958\uB418\uB294 \uACBD\uC6B0\uC5D0\uB294 \uC774\uB1E8\uC81C\uC758 \uC6A9\uB7C9\uC744 \uB192\uC5EC \uCE58\uB8CC\uD558\uBA70, \uB54C\uB54C\uB85C \uC774 \uC57D\uC758 \uC6A9\uB7C9\uC744 \uC904\uC774\uAC70\uB098 \uC77C\uC2DC\uC801\uC73C\uB85C \uD22C\uC57D\uC744 \uC911\uB2E8\uD55C\uB2E4. 2\uC8FC \uC774\uC0C1 \uD734\uC57D\uD558\uC600\uB2E4\uAC00 \uB2E4\uC2DC \uBCF5\uC6A9\uD558\uAE30 \uC2DC\uC791\uD560 \uACBD\uC6B0\uC5D0\uB294 \uCD08\uAE30\uC6A9\uB7C9(1\uC77C 2\uD68C 3.125mg (\uC11C\uBC29\uC131 \uC81C\uC81C\uC758 \uACBD\uC6B0 1\uC77C 1\uD68C 8mg)) \uBD80\uD130 \uC2DC\uC791\uD558\uBA70 \u2018\uC6A9\uBC95\u00B7\uC6A9\uB7C9\u2019\uC5D0 \uB530\uB978\uB2E4.\r\n<P><\/P>11. \uBCF4\uAD00 \uBC0F \uCDE8\uAE09\uC0C1\uC758 \uC8FC\uC758\uC0AC\uD56D\r\n<P><\/P>1) \uC5B4\uB9B0\uC774\uC758 \uC190\uC774 \uB2FF\uC9C0 \uC54A\uB3C4\uB85D \uC8FC\uC758\uD55C\uB2E4.\r\n<P><\/P>2) \uB2E4\uB978 \uC6A9\uAE30\uC5D0 \uBC14\uAFB8\uC5B4 \uB123\uB294 \uAC83\uC740 \uC0AC\uACE0\uC6D0\uC778\uC774 \uB418\uAC70\uB098 \uD488\uC9C8\uC720\uC9C0\uBA74\uC5D0\uC11C \uBC14\uB78C\uC9C1\uD558\uC9C0 \uC54A\uC73C\uBBC0\uB85C \uC774\uB97C \uC8FC\uC758\uD55C\uB2E4.\r\n<P><\/P>\r\n<P><\/P>\r\n<P><\/P>12. \uC804\uBB38\uAC00\uB97C \uC704\uD55C \uC815\uBCF4\r\n<P><\/P>\uAC00. \uC57D\uB3D9\uD559\uC801 \uC815\uBCF4\r\n<P><\/P>1) \uC2DC\uD5D8\uC57D \uB51C\uB77C\uD2B8\uB80C\uC5D0\uC2A4\uC54C\uC81516\uBC00\uB9AC\uADF8\uB7A8(\uCE74\uB974\uBCA0\uB51C\uB864)[\u321C\uC885\uADFC\uB2F9]\uACFC \uB300\uC870\uC57D \uB51C\uB77C\uD2B8\uB80C\uC5D0\uC2A4\uC54C\uCEA1\uC29016\uBC00\uB9AC\uADF8\uB7A8(\uCE74\uB974\uBCA0\uB51C\uB864)[\u321C\uC885\uADFC\uB2F9]\uC744 2\u00D72 \uAD50\uCC28\uC2DC\uD5D8\uC73C\uB85C \uAC01 1\uC815 \uBC0F 1\uCEA1\uC290\uC529 \uAC74\uAC15\uD55C \uC131\uC778\uC5D0\uAC8C \uACF5\uBCF5 \uBC0F \uC2DD\uD6C4 \uC2DC \uB2E8\uD68C \uACBD\uAD6C \uD22C\uC5EC\uD558\uC5EC 45\uBA85(\uACF5\uBCF5) \uBC0F 48\uBA85(\uC2DD\uD6C4)\uC758 \uD608\uC911 \uCE74\uB974\uBCA0\uB51C\uB864\uC744 \uCE21\uC815\uD55C \uACB0\uACFC, \uBE44\uAD50\uD3C9\uAC00\uD56D\uBAA9\uCE58(AUC<SUB>t<\/SUB>, C<SUB>max<\/SUB>)\uB97C \uB85C\uADF8\uBCC0\uD658\uD558\uC5EC \uD1B5\uACC4\uCC98\uB9AC\uD558\uC600\uC744 \uB54C, \uD3C9\uADE0\uCE58 \uCC28\uC758 90% \uC2E0\uB8B0\uAD6C\uAC04\uC774 log 0.8\uC5D0\uC11C log 1.25 \uC774\uB0B4\uB85C\uC11C \uC0DD\uBB3C\uD559\uC801\uC73C\uB85C \uB3D9\uB4F1\uD568\uC744 \uC785\uC99D\uD558\uC600\uB2E4.\r\n<P><\/P>&lt;\uACF5\uBCF5&gt;\r\n<P><\/P>\r\n[&C6]&lt;\uC2DD\uD6C4&gt;\r\n<P><\/P>\r\n[&C7]2)\uC758\uC57D\uD488\uB3D9\uB4F1\uC131\uC2DC\uD5D8\uAE30\uC900 \uC81C7\uC870\uC81C2\uD56D\uC5D0 \uB530\uB77C, \uC2DC\uD5D8\uC57D \uB51C\uB77C\uD2B8\uB80C\uC5D0\uC2A4\uC54C\uC8158\uBC00\uB9AC\uADF8\uB7A8(\uCE74\uB974\uBCA0\uB51C\uB864)[\u321C\uC885\uADFC\uB2F9]\uC740 \uB300\uC870\uC57D \uB51C\uB77C\uD2B8\uB80C\uC5D0\uC2A4\uC54C\uC81516\uBC00\uB9AC\uADF8\uB7A8(\uCE74\uB974\uBCA0\uB51C\uB864)[\u321C\uC885\uADFC\uB2F9]\uACFC\uC758 \uBE44\uAD50\uC6A9\uCD9C\uC2DC\uD5D8\uC790\uB8CC\uB97C \uC81C\uCD9C\uD558\uC600\uC73C\uBA70, \uB300\uC870\uC57D\uACFC \uC6A9\uCD9C\uC591\uC0C1\uC774 \uB3D9\uB4F1\uD558\uC600\uB2E4. \uC774\uC5D0 \uB530\uB77C \uD574\uB2F9 \uC790\uB8CC\uB85C\uC11C \uC0DD\uBB3C\uD559\uC801\uB3D9\uB4F1\uC131\uC744 \uC785\uC99D\uD558\uC600\uB2E4.\r\n<P><\/P>\uB098. \uC784\uC0C1\uC2DC\uD5D8 \uC815\uBCF4\r\n<P><\/P>\uC2EC\uBC29\uC138\uB3D9 \uD658\uC790 135\uBA85\uC744 \uB300\uC0C1\uC73C\uB85C 6\uC8FC \uB3D9\uC548 \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C\uC758 \uC720\uD6A8\uC131\uACFC \uC548\uC804\uC131\uC744 \uD3C9\uAC00\uD558\uAE30 \uC704\uD55C \uB2E4\uAE30\uAD00, \uBB34\uC791\uC704\uBC30\uC815, \uC774\uC911\uB208\uAC00\uB9BC, \uC704\uC57D\uB300\uC870, \uC81C 3\uC0C1 \uC784\uC0C1\uC2DC\uD5D8\uC774 \uC218\uD589\uB418\uC5C8\uB2E4.\r\n<P><\/P>\uC77C\uCC28 \uC720\uD6A8\uC131 \uD3C9\uAC00\uC5D0\uC11C \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C 8~32mg \uD22C\uC5EC\uAD70\uC740 \uAE30\uC800\uCE58 \uB300\uBE44 6\uC8FC \uC9F8 24\uC2DC\uAC04 \uD3C9\uADE0 \uC2EC\uBC15\uC218 \uBCC0\uD654\uB7C9\uC774 \uD1B5\uACC4\uC801\uC73C\uB85C \uC720\uC758\uD558\uAC8C \uAC10\uC18C\uD558\uC600\uACE0, \uC704\uC57D\uAD70\uACFC \uD22C\uC5EC\uAD70\uAC04 \uCC28\uC774\uB3C4 \uD1B5\uACC4\uC801\uC73C\uB85C \uC720\uC758\uD558\uC600\uB2E4. \uC774\uB97C \uD1B5\uD574 \uC704\uC57D\uAD70 \uB300\uBE44 \uCE74\uB974\uBCA0\uB51C\uB864 \uC11C\uBC29\uC131 \uC81C\uC81C \uD22C\uC5EC\uAD70\uC5D0\uC11C \uC2EC\uBC15\uC218 \uAC10\uC18C \uD6A8\uACFC\uAC00 \uC6B0\uC6D4\uD568\uC744 \uC785\uC99D\uD558\uC600\uB2E4.\r\n<P><\/P>[\uD45C] \uAE30\uC800\uCE58 \uB300\uBE44 6\uC8FC \uC9F8 24\uC2DC\uAC04 \uD3C9\uADE0 \uC2EC\uBC15\uC218 \uBCC0\uD654\uB7C9 (bpm)\r\n<P><\/P>\r\n[&C8]\u2020 p-value &lt;0.0001, \uAE30\uC800\uCE58 \uB300\uBE44 \uBCC0\uD654\uB7C9\uC5D0 \uB300\uD55C Paired t-test or Wilcoxon Signed Rank Test \uACB0\uACFC\r\n<P><\/P>\u2021 p-value &lt;0.0001, \uD22C\uC5EC\uAD70 \uAC04 Mean \uBE44\uAD50\uB97C \uC704\uD55C Independent samples t-test or Wilcoxon Rank Sum Test\r\n<P><\/P>","idfylength":"11.1|5.6|3.8|\uBD84\uD64D\uC0C9\uC758 \uC7A5\uBC29\uD615 \uC11C\uBC29\uC815|SR8|\uBD84\uD560\uC120|50730|32246|2020041700010|||\uB4F1\uB85D|\uB4F1\uB85D\uC644\uB8CC|2020-09-24","boh":"362\uC6D0\/1\uC815","etc":"","idfyidx":50730,"reexam":null,"reexam_start_date":"","reexam_end_date":"","item_ingr_type":"1","additives":"\uADDC\uD654\uBBF8\uACB0\uC815\uC140\uB8F0\uB85C\uC624\uC2A4<\/br>\uAE00\uB9AC\uC138\uB9B4\uBCA0\uD5E4\uB124\uC774\uD2B8<\/br>\uBA54\uD0C0\uADDC\uC0B0\uC54C\uB8E8\uBBFC\uC0B0\uB9C8\uADF8\uB124\uC298<\/br>\uC624\uD30C\uB4DC\uB77C\uC774\uBD84\uD64D\uC0C9(03B54202)<\/br>\uD06C\uB85C\uC2A4\uD3EC\uBE44\uB3C8"}]